Evidence map›Paper›PMID 30977112›Full record

ArticleInternational journal of cancer2019

Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2

Zhongming Ge, Yan Feng, Alexander Sheh, Sureshkumar Muthupalani, Guanyu Gong, Supawadee Chawanthayatham, John M Essigmann, James G Fox

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Male-Dependent Promotion of Colitis in 129International journal of molecular sciences · 2020
    Article
  5. Gut Microbiota and Colon Cancer: A Role for Bacterial Protein Toxins?International journal of molecular sciences · 2020
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhongming GeDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
Yan FengDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alexander ShehDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sureshkumar MuthupalaniDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
Guanyu GongDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
Supawadee ChawanthayathamDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
John M EssigmannDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
James G FoxDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-9307-6116
Massachusetts Institute of Technology · US

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6M
Reaction and Diffusion of NO in Biological SystemsP01CA026731 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2018
$25.4M
Intra and Extra-Chromosomal Probes for Mutagenesis by CarcinogensR01CA080024 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1998 to 2025
$5.9M
Biomedical Research Training for Veterinary ScientistsT32OD010978 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FOX, JAMES G · 2012 to 2017
$2.2M
NCI NIH HHS P01 CA026731NCI NIH HHS R01 CA080024NIEHS NIH HHS P30 ES002109NIH HHS R01-OD01141NIH HHS T32 OD010978
6 · The paper itself

Abstract

Inflammatory bowel disease and colonic tumors induced by Helicobacter hepaticus (Hh) infection in susceptible mouse strains are utilized to dissect the mechanisms underlying similar human diseases. In our study, infection with genotoxic cytolethal distending toxin-producing Hh in 129/SvEv Rag2

Indexed as

AnimalsColonDNA-Binding ProteinsEpithelial CellsFemaleHelicobacter hepaticusHelicobacter InfectionsInflammationInflammatory Bowel DiseasesInterleukin-10Interleukin-17Intestinal MucosaMaleMiceMutagenesisMutationDNA-Binding ProteinsIL10 protein, mouseInterleukin-10Interleukin-17Rag2 protein, mouseRNA, MessengerTumor Necrosis Factor-alphacolitisDSBsH. hepaticusiNos expressionmutation promotion

Identifiers

PMID30977112
PMCPMC6724725
OpenAlexW2936534027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.