Evidence map›Paper›PMID 30977102›Full record

ArticleNeurotoxicity research2019

Neurotrophin Receptor p75 mRNA Level in Peripheral Blood Cells of Patients with Alzheimer's Disease.

Yali Xu, Wei-Wei Li, Jun Wang, Chi Zhu, Ying-Ying Shen, An-Yu Shi, Gui-Hua Zeng, Zhi-Qiang Xu, Xin-Fu Zhou, Yan-Jiang Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yali XuDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Wei-Wei LiDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Jun WangDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Chi ZhuDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Ying-Ying ShenDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
An-Yu ShiDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Gui-Hua ZengDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Zhi-Qiang XuDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Xin-Fu ZhouDivision of Health Sciences, School of Pharmacy and Medical Sciences and Sansom Institute, University of South Australia, Adelaide, South Australia, Australia.
Yan-Jiang WangDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China. yanjiang_wang@tmmu.edu.cn.
Army Medical University · CNDaping Hospital · CNUniversity of Chinese Academy of Sciences · CNUniversity of South Australia · AU

Funding

China Postdoctoral Science Foundation 2017M623365Chongqing Postdoctoral Projects Xm2017029National Natural Science Foundation of China 81625007
6 · The paper itself

Abstract

The neurotrophin receptor p75 (p75NTR) plays important roles in regulating amyloid-beta (Aβ) metabolism in the brain. The expression of p75NTR is altered in the brain of patients with Alzheimer's disease (AD). In this study, we aimed to evaluate whether p75NTR mRNA level in the peripheral blood cells is changed among AD patients and its potential to be a biomarker for AD. The study subjects included 26 patients with AD (PiB-PET positive) and 28 cognitively normal controls (PiB-PET negative). RNA was extracted from peripheral blood cells of fast blood. p75NTR mRNA was measured using quantitative real-time PCR assay. p75NTR mRNA levels in blood cells were comparable between AD patients and controls. p75NTR mRNA levels in blood cells were not correlated with MMSE scores, ApoE genotypes, gender, and age. p75NTR mRNA expression in blood cells is not changed in AD patients and is unlikely to be a biomarker for AD.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseApolipoproteins EBiomarkersFemaleHumansMaleMiddle AgedNerve Tissue ProteinsReceptors, Nerve Growth FactorRNA, MessengerApoE protein, humanApolipoproteins EBiomarkersNerve Tissue ProteinsNGFR protein, humanReceptors, Nerve Growth FactorRNA, MessengerAlzheimer’s disease (AD)mRNAp75 neurotrophin receptor (p75NTR)Pittsburgh compound B (PiB)

Identifiers

PMID30977102
OpenAlexW2939344084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.