Evidence map›Paper›PMID 30977096›Full record

ArticleHead and neck pathology2020

Patterns of LC3A Autophagy Protein Expression in Keratoacanthomas.

Efthimios Sivridis, Ioannis M Koukourakis, Stella Arelaki, Kostantina Balaska, Antonios Karpouzis, Alexandra Giatromanolaki

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Efthimios SivridisDepartments of Pathology, Democritus University of Thrace Medical School and University General Hospital of Alexandroupolis, 68100, Alexandroupolis, Greece. esivrid@med.duth.gr.
Ioannis M KoukourakisDepartments of Pathology, Democritus University of Thrace Medical School and University General Hospital of Alexandroupolis, 68100, Alexandroupolis, Greece.
Stella ArelakiDepartments of Pathology, Democritus University of Thrace Medical School and University General Hospital of Alexandroupolis, 68100, Alexandroupolis, Greece.
Kostantina BalaskaDepartments of Pathology, Democritus University of Thrace Medical School and University General Hospital of Alexandroupolis, 68100, Alexandroupolis, Greece.
Antonios KarpouzisDepartments of Dermatology, Democritus University of Thrace Medical School and University General Hospital of Alexandroupolis, 68100, Alexandroupolis, Greece.
Alexandra GiatromanolakiDepartments of Pathology, Democritus University of Thrace Medical School and University General Hospital of Alexandroupolis, 68100, Alexandroupolis, Greece.ORCID http://orcid.org/0000-0003-3706-8845
Democritus University of Thrace · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the expression patterns of autophagy marker light chain protein 3 (LC3A) in keratoacanthoma (KA). KAs are generally regarded as benign but malignant behavior, including rare metastases, may occur. 85 KAs were assessed for the LC3A autophagic protein by immunohistochemistry. Diffuse cytoplasmic staining and a "stone-like structure" (SLS) characterized positive expression. Thirty-four out of 85 KAs (40%) had diffuse cytoplasmic LC3A immunostaining (percentage of positive cells ranging from 5 to 60%). In contrast, only 4 of the 85 KAs (4.7%) expressed SLSs. Only one SLS was detected per histologic section of each tumor. The p53 oncoprotein was encountered in all cases with expression ranging from 1 to 90% of cells (median 30%). The Ki-67 index was expressed in 63 cases (74% of cases; range 1-50% of cells; median value 5%). Neither of these two parameters nor diffuse cytoplasmic LC3A staining was significantly correlated with SLS expression or lack thereof. Expression of SLSs, a hallmark of malignancy, was found in 4.7% of KAs. Further study is necessary to determine whether this fraction represents the exceptional cases that harbor latent malignant potential.

Indexed as

AgedAged, 80 and overAutophagyBiomarkers, TumorFemaleHumansKeratoacanthomaMaleMicrotubule-Associated ProteinsMiddle AgedRetrospective StudiesSkin NeoplasmsBiomarkers, TumorMAP1LC3A protein, humanMicrotubule-Associated ProteinsAutophagyKeratoacanthomaKi67LC3AP53Stone-like structures

Identifiers

PMID30977096
PMCPMC7021871
OpenAlexW2936083766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.