ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020
Effect of cardiac resynchronization therapy on septal perfusion and septal thickening: Association with left ventricular function, reverse remodelling and dyssynchrony.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Effects of stress on myocardial perfusion and left ventricular synchrony in patients undergoing left bundle branch area pacing.European journal of nuclear medicine and molecular imaging · 2026Article
- The application of radiology for dilated cardiomyopathy diagnosis, treatment, and prognosis prediction: a bibliometric analysis.Quantitative imaging in medicine and surgery · 2023Article
- Technical aspects of gated SPECT MPI assessment of left ventricular dyssynchrony used in the VISION-CRT study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Intraventricular synchronism assessment by gated-SPECT myocardial perfusion imaging in cardiac resynchronization therapy. Does cardiomyopathy type influence results?EJNMMI research · 2020Article
- Refining the role of gated SPECT for predicting clinical response to cardiac resynchronization therapy: Are we using the right tool at the wrong time?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
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Authors and funding
15 authors at 12 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe evaluated the effect of cardiac resynchronization therapy (CRT) on septal perfusion and thickening at 6 months post implantation assessed on Tc99m-MIBI Gated myocardial perfusion SPECT (GMPS).We also studied the association of change in septal perfusion and thickening with primary outcome defined as at least one [improvement in ≥1NYHA class, left ventricular ejection fraction (LVEF) by ≥ 5%, reduction of end-systolic volume (ESV) by ≥ 15%, and improvement ≥ 5 points in Minnesota living with heart failure questionnaire (MLHFQ)].
methodOne hundred and five patients underwent clinical and GMPS evaluation before and at 6 months post CRT.
resultPost CRT there was significant improvement in mean normalized septal perfusion uptake and in septal thickening (P value = 0.001, both). There was no significant relation between improvement in septal perfusion and primary outcome. However, improvement in septal thickening was statistically significant with favorable primary outcome (P = 0.001).There was no significant correlation between improvement of septal perfusion and improvement in LVEF, reduction in End diastolic volume (EDV), ESV, and Left ventricular Dyssynchrony (LVD). But, there was significant correlation between improvement of septal thickening and these parameters.
conclusionImprovement in septal thickening was associated with reverse remodeling, improvement in LVEF, and reduction of LVD.
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Registered trials
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