Evidence map›Paper›PMID 30977086›Full record

ArticleMolecular biology reports2019

Strong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriots.

Gulten Tuncel, Sehime Gulsun Temel, Mahmut Cerkez Ergoren

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  6. Association between single nucleotide polymorphisms in vitamin D related and parathyroid hormone genes with nonsyndromic oral cleft.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025
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  15. Article
  16. Vitamin D receptor gene polymorphisms in atopy.Immunity, inflammation and disease · 2021
    Review
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  18. Impact of FokI (rs2228570) and BglI (rs739837) polymorphisms inJournal of oral biology and craniofacial research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Gulten TuncelDepartment of Medical Biology, Faculty of Medicine, Near East University, 99138, Nicosia, Cyprus.ORCID http://orcid.org/0000-0002-3332-471X
Sehime Gulsun TemelDepartment of Medical Genetics, Faculty of Medicine, Uludag University, Bursa, Turkey.ORCID http://orcid.org/0000-0002-9802-0880
Mahmut Cerkez ErgorenDepartment of Medical Biology, Faculty of Medicine, Near East University, 99138, Nicosia, Cyprus. mahmutcerkez.ergoren@neu.edu.tr.ORCID http://orcid.org/0000-0001-9593-9325
Near East University · CYBursa Uludağ Üni̇versi̇tesi̇ · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D is an important molecule to keep teeth, bones and muscles healthy. It is obtained from diet, supplements and primarily from exposure to sunlight. In recent years, vitamin D deficiency is recognised as a worldwide health problem, which results in disturbances in mineral metabolism and skeletal problems. Deficiency might be caused due to sedentary lifestyle, insufficient diet, age as well as some polymorphisms in the VDR gene. In this study the four most common VDR polymorphisms (rs1544410 (BsmI), rs731236 (TaqI), rs7975232 (ApaI) and rs2228570 (FokI)) are investigated in a cohort of Turkish Cypriots and aimed to detect any possible links between low serum vitamin D levels and these variants. The rs2228570 (FokI) variant but not others were shown to have a significant association with decreased serum vitamin D levels in the Turkish Cypriot population.

Indexed as

AdultAgedCase-Control StudiesCyprusFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedOdds RatioPolymorphism, Single NucleotideReceptors, CalcitriolRisk FactorsReceptors, CalcitriolVDR protein, humanVitamin DCyprusPolymorphismVDRVitamin D deficiency

Identifiers

PMID30977086
OpenAlexW2939285544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.