ReviewCurrent nutrition reports2019
Coffee Drinking and Reduced Risk of Liver Cancer: Update on Epidemiological Findings and Potential Mechanisms.
Review in Current nutrition reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large-Scale, Multicenter Study.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Association of daily diet and incidence of head and neck cancer: a prospective cohort study of UK biobank participants.European journal of nutrition · 2026Observational
- The effect of continuous infusion chemotherapy through femoral artery catheterization on GP73, AFP-L3, and safety efficacy in liver cancer patients.Clinical and experimental medicine · 2025Article
- Integrated microbiome and metabolome analysis reveals the interaction between intestinal flora and serum metabolites as potential biomarkers in hepatocellular carcinoma patients.Frontiers in cellular and infection microbiology · 2023Article
- Severe liver fibrosis in the HCV cure era: Major effects of social vulnerability, diabetes, and unhealthy behaviors.JHEP reports : innovation in hepatology · 2022Article
- Targeting transforming growth factor-β signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin.Clinical and translational medicine · 2022Review
- Coffee reduces the risk of hepatocellular carcinoma probably through inhibition of NLRP3 inflammasome activation by caffeine.Frontiers in oncology · 2022Article
- An investigation of cross-sectional associations of a priori-selected dietary components with circulating bile acids.The American journal of clinical nutrition · 2021Article
- Article
- Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewWe reviewed the available literature on observational studies, meta-analyses, expert reports, and umbrella reviews. Here, we summarize the latest findings on the association between coffee intake and liver cancer risk. RECENT
findingsMost observational studies and meta-analyses show a protective effect of coffee intake on liver cancer risk, with dose-responsiveness and across different populations, and regardless of hepatitis virus infection status. Risk reduction by coffee consumption has also been observed for chronic liver diseases. Potential mechanisms include the effect of a number of bioactive compounds such as caffeine, chlorogenic acids, phenolic compounds and diterpenes; antioxidant properties; induction of defense mechanisms; and anti-inflammatory properties. Other potential mechanisms include improvement in insulin sensitivity and prevention of metabolic syndrome and diabetes. Accumulated evidence, with consistency across study designs and populations, suggests that coffee intake probably reduces the risk of liver cancer. Future research should aim to elucidate the mechanism of this preventive effect with establishing the causality of an association.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.