ArticleNeuroscience bulletin2019
High-Throughput Automatic Training System for Spatial Working Memory in Free-Moving Mice.
Article in Neuroscience bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats.eNeuro · 2026Article
- A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats.bioRxiv : the preprint server for biology · 2025Article
- Distinct Effects of Social Stress on Working Memory in Obsessive-Compulsive Disorder.Neuroscience bulletin · 2021Article
- "Transient" or "Persistent" Coding for Working Memory.Neuroscience bulletin · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficient behavioral assays are crucial for understanding the neural mechanisms of cognitive functions. Here, we designed a high-throughput automatic training system for spatial cognition (HASS) for free-moving mice. Mice were trained to return to the home arm and remain there during a delay period. Software was designed to enable automatic training in all its phases, including habituation, shaping, and learning. Using this system, we trained mice to successfully perform a spatially delayed nonmatch to sample task, which tested spatial cognition, working memory, and decision making. Performance depended on the delay duration, which is a hallmark of working memory tasks. The HASS enabled a human operator to train more than six mice simultaneously with minimal intervention, therefore greatly enhancing experimental efficiency and minimizing stress to the mice. Combined with the optogenetic method and neurophysiological techniques, the HASS will be useful in deciphering the neural circuitry underlying spatial cognition.
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Registered trials
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