ReviewCurrent pain and headache reports2019
Metabolic and the Surgical Stress Response Considerations to Improve Postoperative Recovery.
Review in Current pain and headache reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Preoperative carbohydrate loading in elective colorectal surgery: postoperative complications and outcomes, a systematic review and meta-analysis.International journal of colorectal disease · 2026Pooled it
- Enhanced recovery after surgery protocols for the perioperative management of pediatric cleft lip and palate surgery: a systematic review and meta-analysis.Pediatric surgery international · 2025Pooled it
- Quality of fluid balance charting and interventions to improve it: a systematic review.BMJ open quality · 2023Pooled it
- The effect of preoperative oral carbohydrate intake on perioperative well-being in patients undergoing hip and lower extremity orthopedic surgery under spinal anesthesia: a randomized controlled trial.Langenbeck's archives of surgery · 2025Trial
- Trial
- The Association Between Postoperative Fluid Balance and Postoperative Complications in Adults Undergoing Gastrointestinal Surgery: Protocol for a Scoping Review.Acta anaesthesiologica Scandinavica · 2026Article
- Frailty, physiological reserve, and surgical resilience: toward a dynamic stress-recovery model.Aging clinical and experimental research · 2026Review
- The impact of preoperative psychological status on postoperative stress responses in patients undergoing dynamic hip screw fixation.Medicine · 2026Article
- Predictive value of preoperative and postoperative controlling nutritional status scores and their changes in older patients with large vessel occlusion stroke after endovascular thrombectomy.Frontiers in nutrition · 2026Article
- Surgical Stress Response: A Physiological Review of the Endocrine, Immune, and Metabolic Changes.Cureus · 2025Review
- Design and application of a novel surgical transfer sheet: a randomized controlled trial.BMC nursing · 2025Article
- Combined impact of nutritional and inflammatory status and depressive symptoms on mortality following hysterectomy.BMC women's health · 2025Article
- The effect of preoperative oral carbohydrate on the perioperative period of fibula free flap surgery in patients with oral cancer: a retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Summary of best evidence for enhanced recovery after surgery for perioperative management of pediatric cleft lip and palate surgery: a narrative review.Translational pediatrics · 2025Review
- Perioperative fluid therapy impairs lymphatic pump function in male rats.Physiological reports · 2025Article
- Article
- Efficacy and safety of massage for postoperative stress in colorectal cancer patients: a randomized, controlled, three-arm trial.Frontiers in oncology · 2025Article
- Comparison of early outcomes between unicompartmental and total knee arthroplasty in patients with anteromedial compartment knee osteoarthritis and class II obesity: a retrospective case analysis.Frontiers in surgery · 2025Review
- Nutritional trajectories in gastric cancer patients with early oral feeding.Frontiers in nutrition · 2025Article
- Quantifying fluid retention following modern pain management in TKA: an observational study.Knee surgery & related research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewEnhanced recovery pathways are a multimodal, multidisciplinary approach to patient care that aims to reduce the surgical stress response and maintain organ function resulting in faster recovery and improved outcomes. RECENT
findingsA PubMed literature search was performed for articles that included the terms of metabolic surgical stress response considerations to improve postoperative recovery. The surgical stress response occurs due to direct and indirect injuries during surgery. Direct surgical injury can result from the dissection, retraction, resection, and/or manipulation of tissues, while indirect injury is secondary to events including hypotension, blood loss, and microvascular changes. Greater degrees of tissue injury will lead to higher levels of inflammatory mediator and cytokine release, which ultimately drives immunologic, metabolic, and hormonal processes in the body resulting in the stress response. These processes lead to altered glucose metabolism, protein catabolism, and hormonal dysregulation among other things, all which can impede recovery and increase morbidity. Fluid therapy has a direct effect on intravascular volume and cardiac output with a resultant effect on oxygen and nutrient delivery, so a balance must be maintained without excessively loading the patient with water and salt. All in all, attenuation of the surgical stress response and maintaining organ and thus whole-body homeostasis through enhanced recovery protocols can speed recovery and reduce complications. The present investigation summarizes the clinical application of enhanced recovery pathways, and we will highlight the key elements that characterize the metabolic surgical stress response and improved postoperative recovery.
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