Evidence map›Paper›PMID 30976936›Full record

ArticlePharmaceutical research2019

Lipid-Coated, pH-Sensitive Magnesium Phosphate Particles for Intracellular Protein Delivery.

Yunzhou Fang, Mallika Vadlamudi, Yingbo Huang, Xin Guo

Abstract read
PubMed Publisher
In one paragraph

Article in Pharmaceutical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Coarse-Grained Molecular Dynamics of pH-Sensitive Lipids.International journal of molecular sciences · 2023
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yunzhou FangDepartment of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, 751 Brookside Road, Stockton, California, 95211, USA.
Mallika VadlamudiDepartment of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, 751 Brookside Road, Stockton, California, 95211, USA.
Yingbo HuangDepartment of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, 751 Brookside Road, Stockton, California, 95211, USA.
Xin GuoDepartment of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, 751 Brookside Road, Stockton, California, 95211, USA. xguo@pacific.edu.ORCID http://orcid.org/0000-0002-0093-7085
University of the Pacific · US

Funding

National Institutes of Health GM107823
6 · The paper itself

Abstract

purposeTo develop cationic lipid-coated magnesium phosphate nanoparticles (LPP) for intracellular catalase (CAT) delivery.

methodsMagnesium phosphate nanoparticles (MgP NP) were prepared by micro-emulsion precipitation and mixed with catalase-loaded cationic liposomes (DOTAP/cholesterol) to yield LPP formulation of catalase (LPP-CAT). The size and ζ-potential of LPP-CAT were measured by dynamic light scattering. The pH-sensitivity of LPP-CAT was determined by monitoring their degradation of hydrogen peroxide (H

resultsLPP-CAT were successfully prepared and carried an average diameter of <300 nm and ζ -potential of about +40 mV. At pH 5.5, LPP-CAT degraded H

conclusionLPP represents a promising nano-system for intracellular protein delivery.

Indexed as

CatalaseCell LineCell SurvivalCholesterolDrug CarriersDrug LiberationFatty Acids, MonounsaturatedHumansHydrogen-Ion ConcentrationHydrogen PeroxideLipidsLiposomesMagnesium CompoundsMetal NanoparticlesParticle SizePhosphates1,2-dioleoyloxy-3-(trimethylammonium)propaneCatalaseCholesterolDrug CarriersFatty Acids, MonounsaturatedHydrogen PeroxideLipidsLiposomesMagnesium Compoundsmagnesium phosphatePhosphatesQuaternary Ammonium Compoundsintracellular deliveryliposomemagnesium phosphate nanoparticlesprotein deliverytriggered release

Identifiers

PMID30976936
OpenAlexW2939422179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.