Evidence map›Paper›PMID 30976899›Full record

ArticlePediatric nephrology (Berlin, Germany)2019

Association of low birth weight and prematurity with clinical outcomes of childhood nephrotic syndrome: a prospective cohort study.

Natalia Konstantelos, Tonny Banh, Viral Patel, Jovanka Vasilevska-Ristovska, Karlota Borges, Neesha Hussain-Shamsy, Damien Noone, Diane Hebert, Seetha Radhakrishnan, Christoph P B Licht and 3 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01605266 (INSIGHT), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01605266 recruitingnot on this map

INSIGHT (Insight Into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics)

TypeobservationalSponsorThe Hospital for Sick ChildrenRan2011 to 2032Enrolled1,000ConditionsNephrotic Syndrome
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Kidney care at NICU discharge and follow-up recommendations for preterm infants<34 weeks.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Natalia KonstantelosChild Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada.
Tonny BanhChild Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada.
Viral PatelUniversity of Toronto, 27 King's College Cir, Toronto, ON, M5S 3H7, Canada.
Jovanka Vasilevska-RistovskaChild Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada.
Karlota BorgesChild Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada.
Neesha Hussain-ShamsyUniversity of Toronto, 27 King's College Cir, Toronto, ON, M5S 3H7, Canada.
Damien NooneUniversity of Toronto, 27 King's College Cir, Toronto, ON, M5S 3H7, Canada.
Diane HebertUniversity of Toronto, 27 King's College Cir, Toronto, ON, M5S 3H7, Canada.
Seetha RadhakrishnanUniversity of Toronto, 27 King's College Cir, Toronto, ON, M5S 3H7, Canada.
Christoph P B LichtUniversity of Toronto, 27 King's College Cir, Toronto, ON, M5S 3H7, Canada.
Valerie LangloisUniversity of Toronto, 27 King's College Cir, Toronto, ON, M5S 3H7, Canada.
Rachel J PearlUniversity of Toronto, 27 King's College Cir, Toronto, ON, M5S 3H7, Canada.
Rulan S ParekhChild Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada. rulan.parekh@sickkids.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow birth weight (LBW)/prematurity have been proposed as risk factors for the development of kidney disease in adulthood. Whether there is an association between LBW/prematurity and poor renal outcomes in childhood onset nephrotic syndrome remains unknown.

methodsChildren with nephrotic syndrome diagnosed between 1 and 18 years of age were followed prospectively from 1996 to 2016 at The Hospital for Sick Children (N = 377). LBW/prematurity was defined as birth weight < 2500 g or gestational age < 36 weeks. Normal birth weight (NBW) was defined as birth weight ≥ 2500 g. Measures evaluating clinical course of nephrotic syndrome include initial steroid-resistant nephrotic syndrome (SRNS), time to first relapse, and frequently relapsing nephrotic syndrome. Kaplan-Meier survival analysis, logistic regression, and Cox proportional hazards regression were used to determine the association of LBW/prematurity with clinical outcomes.

resultsMedian birth weights in LBW/premature (n = 46) and NBW (n = 331) children were 2098 g (interquartile range [IQR] 1700-2325 g) and 3317 g (IQR 2977-3685 g), respectively. Odds of having SRNS were 3.78 (95% confidence interval [CI] 1.28-11.21) times higher among LBW/premature children than NBW children. An 8% decrease in odds of developing SRNS was observed for every 100 g increase in birth weight (adjusted odds ratio [OR] 0.92; 95% CI 0.86-0.98). Median time to first relapse did not differ (hazard ratio [HR] 0.89; 95% CI 0.53-1.16).

conclusionsLBW/premature children were more likely to develop SRNS but did not have a difference in time to first relapse with NBW children. Understanding the impact and mechanism of birth weight and steroid-resistant disease needs further study.

Indexed as

AdolescentAge of OnsetBirth WeightChildChild, PreschoolDrug ResistanceFemaleGestational AgeGlucocorticoidsHumansInfant, Low Birth WeightInfant, NewbornInfant, PrematureKidneyMaleNephrotic SyndromeGlucocorticoidsLow birth weightNephrotic syndromePrematuritySteroid resistant nephrotic syndromeTime to first relapse

Identifiers

PMID30976899

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.