Evidence map›Paper›PMID 30976614›Full record

ArticleGE Portuguese journal of gastroenterology2019

Effect of Meal Ingestion on Liver Stiffness and Controlled Attenuation Parameter.

Marco Silva, Pedro Costa Moreira, Armando Peixoto, Ana Luísa Santos, Susana Lopes, Regina Gonçalves, Pedro Pereira, Hélder Cardoso, Guilherme Macedo

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in GE Portuguese journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07206004 (Effect of Parenteral Nutrition/Fluids on FibroScan Results in Patients With Short Bowel Syndrome), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07206004 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Parenteral Nutrition/Fluids on FibroScan Results in Patients With Short Bowel Syndrome

TypeobservationalSponsorRigshospitalet, DenmarkRan2026 to 2027Enrolled20ConditionsShort Bowel Syndrome, Intestinal Failure, Liver DiseasesArmsFibroscan
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
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  10. Fibroscan® probe selection for lean adults.JGH open : an open access journal of gastroenterology and hepatology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Marco SilvaDepartment of Gastroenterology, Centro Hospitalar de São João, Porto Medical School, Porto, Portugal.
Pedro Costa MoreiraDepartment of Gastroenterology, Centro Hospitalar de São João, Porto Medical School, Porto, Portugal.
Armando PeixotoDepartment of Gastroenterology, Centro Hospitalar de São João, Porto Medical School, Porto, Portugal.
Ana Luísa SantosDepartment of Gastroenterology, Centro Hospitalar de São João, Porto Medical School, Porto, Portugal.
Susana LopesDepartment of Gastroenterology, Centro Hospitalar de São João, Porto Medical School, Porto, Portugal.
Regina GonçalvesDepartment of Gastroenterology, Centro Hospitalar de São João, Porto Medical School, Porto, Portugal.
Pedro PereiraDepartment of Gastroenterology, Centro Hospitalar de São João, Porto Medical School, Porto, Portugal.
Hélder CardosoDepartment of Gastroenterology, Centro Hospitalar de São João, Porto Medical School, Porto, Portugal.
Guilherme MacedoDepartment of Gastroenterology, Centro Hospitalar de São João, Porto Medical School, Porto, Portugal.
Hospital de São João · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsDespite the increasing use of noninvasive methods for the assessment of liver fibrosis and steatosis, the effect of fasting and food intake on these parameters is not yet clear. Our aims were to evaluate the effect of food intake on liver stiffness (LS) (measured by transient elastography) and controlled attenuation parameter (CAP) in patients with different degrees of liver disease and healthy volunteers, and secondarily, to assess possible factors associated with variations of LS and CAP.

methodsWe performed a prospective single-center study including patients with liver disease and healthy volunteers. LS and CAP were evaluated using FibroScan® (Echosens, Paris, France), before (fasting ≥8 h) and 30 min after intake of a standardized breakfast. We used common cutoffs for LS: > 7 kPa for significant fibrosis (F2 to F4) and > 11 to 14 kPa (mean 12.5 kPa) for cirrhosis.

resultsFifty-nine (72%) patients with liver disease and 22 (28%) healthy volunteers were included. LS significantly increased 30 min after food intake (pre-meal 6.1 kPa [IQR: 4.7-9.8] vs. after-meal 6.8 kPa [IQR: 5.5-10.6];

conclusionsSignificant variations of LS were observed after ingestion of a standard meal, which may have consequences for patient management. CAP values were not significantly affected by food intake. Therefore, we consider that before the isolated evaluation of CAP, it is not necessary to perform any fasting period.

Indexed as

FibroscanHealthy volunteersLiver disease

Identifiers

PMID30976614
PMCPMC6454378
OpenAlexW2799291720

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.