Evidence map›Paper›PMID 30976472›Full record

ArticleIEEE access : practical innovations, open solutions2018

A Programmable Multi-biomarker Neural Sensor for Closed-loop DBS.

Mahboubeh Parastarfeizabadi, Abbas Z Kouzani, Jaclyn Beckinghausen, Tao Lin, Roy V Sillitoe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IEEE access : practical innovations, open solutions, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Multi-disease Deep Brain Stimulation.IEEE access : practical innovations, open solutions · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Mahboubeh ParastarfeizabadiSchool of Engineering, Deakin University, Geelong, VIC 3216, Australia.
Abbas Z KouzaniSchool of Engineering, Deakin University, Geelong, VIC 3216, Australia.
Jaclyn BeckinghausenDepartment of Pathology and Immunology, Department of Neuroscience, and Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston Texas 77030, USA.
Tao LinDepartment of Pathology and Immunology, and Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston Texas 77030, USA.
Roy V SillitoeDepartment of Pathology and Immunology, Department of Neuroscience, Program in Developmental Biology, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston Texas 77030, USA.
Deakin University · AUNeurological Research Institute · USBaylor College of Medicine · US

Funding

Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
CEREBELLAR FUNCTION IN TREMORR01NS100874 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2017 to 2021
$1.9M
SYNAPTIC ORIGINS OF CEREBELLAR DISEASER01NS089664 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2014 to 2018
$1.7M
NICHD NIH HHS U54 HD083092NINDS NIH HHS R01 NS089664NINDS NIH HHS R01 NS100874
6 · The paper itself

Abstract

Most of the current closed-loop DBS devices use a single biomarker in their feedback loop which may limit their performance and applications. This paper presents design, fabrication, and validation of a programmable multi-biomarker neural sensor which can be integrated into closed-loop DBS devices. The device is capable of sensing a combination of low-frequency (7-45 Hz), and high-frequency (200-1000 Hz) neural signals. The signals can be amplified with a digitally programmable gain within the range 50-100 dB. The neural signals can be stored into a local memory for processing and validation. The sensing and storage functions are implemented via a combination of analog and digital circuits involving preamplifiers, filters, programmable post-amplifiers, microcontroller, digital potentiometer, and flash memory. The device is fabricated, and its performance is validated through: (i) bench tests using sinusoidal and pre-recorded neural signals, (ii) in-vitro tests using pre-recorded neural signals in saline solution, and (iii) in-vivo tests by recording neural signals from freely-moving laboratory mice. The animals were implanted with a PlasticsOne electrode, and recording was conducted after recovery from the electrode implantation surgery. The experimental results are presented and discussed confirming the successful operation of the device. The size and weight of the device enable tetherless back-mountable use in pre-clinical trials.

Indexed as

CircuitsClosed-loopMultiple BiomarkersNeural sensorProgrammable

Identifiers

PMID30976472
PMCPMC6453143
OpenAlexW2904231691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.