ArticlePeerJ2019
A longitudinal study of the faecal microbiome and metabolome of periparturient mares.
Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- A Comprehensive Review of the Equine Gut Microbiome in Health and Disease.Veterinary sciences · 2026Review
- The bacterial faecal microbiota shifts during the transition period in dairy cows.Animal microbiome · 2025Article
- Gastro-Intestinal Microbiota in Equines and Its Role in Health and Disease: The Black Box Opens.Microorganisms · 2022Review
- Comparison of the Fecal Microbiota of Horses with Intestinal Disease and Their Healthy Counterparts.Veterinary sciences · 2021Article
- Comparison of the Gut Microbiota of Jeju and Thoroughbred Horses in Korea.Veterinary sciences · 2021Article
- A Comparison of the Colonic Microbiome and Volatile Organic Compound Metabolome ofAnimals : an open access journal from MDPI · 2021Article
- Acute changes in the colonic microbiota are associated with large intestinal forms of surgical colic.BMC veterinary research · 2019Article
- Changes in the gut microbiome and colic in horses: Are they causes or consequences?Open veterinary journalReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriparturient mares are at increased risk of colic including large colon volvulus, which has a high mortality rate. Alterations in colonic microbiota related to either physiological or management changes, or both, that occur at this time have been suggested as potential causes for increased colic risk in this population of horses. Although the effect of management changes on the horse faecal microbiota has been investigated, limited work has been conducted to investigate changes in faecal microbiota structure and function in the periparturient period. The objectives of the current study were to investigate temporal stability of the faecal microbiota and volatile organic compounds (VOCs) of the faecal metabolome in periparturient mares.
methodsFaecal samples were collected weekly from five pregnant mares from 3 weeks pre-foaling to 7 weeks post-foaling. The microbiome data was generated by PCR amplification and sequencing of the V1-V2 regions of the bacterial 16S rRNA genes, while the VOC profile was characterised using headspace solid phase microextraction gas chromatography mass spectrometry.
resultsThe mare faecal microbiota was relatively stable over the periparturient period and most variation was associated with individual mares. A small number of operational taxonomic units were found to be significantly differentially abundant between samples collected before and after foaling. A total of 98 VOCs were identified. The total number of VOCs did not vary significantly between individual mares, weeks of sample collection and feeds available to the mares. Three VOCs (decane, 2-pentylfuran, and oct-2-ene) showed significant increase overtime on linear mixed effects modelling analysis. These results suggest that the mare faecal microbiota is structurally and functionally stable during the periparturient period. The findings also suggest that if changes in the gut microbiota are related to development of colic postpartum, altered risk may be due to inherent differences between individual mares. VOCs offer a cost-effective means of looking at the functional changes in the microbiome and warrant further investigation in mares at risk of colic.
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