ArticleGastroenterology report2019
Radiation-induced injury on surgical margins: a clue to anastomotic leakage after rectal-cancer resection with neoadjuvant chemoradiotherapy?
Article in Gastroenterology report, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05607927 (Laparoscopic Proximally Extended Colorectal Resection With Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis for Late Complications of Chronic Radiation-induced Rectal Injury), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Laparoscopic Proximally Extended Colorectal Resection With Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis for Late Complications of Chronic Radiation-induced Rectal Injury: A Prospective, Multicenter, Randomized Controlled Clinical Trail
Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Effect of interval between preoperative radiotherapy and surgery on clinical outcome and radiation proctitis in rectal cancer from FOWARC trial.Cancer medicine · 2020Trial
- Comparison of surgical safety among different comprehensive treatment models for adenocarcinoma of esophagogastric junction: a single-center cohort study.BMC gastroenterology · 2026Observational
- Standardized surgical procedure of proximally extended resection and sphincter-preserving surgery (Tianhe Procedure) for rectal cancer after radiotherapy (2025 version).Gastroenterology report · 2026Article
- Machine learning for predicting surgical difficulty of laparoscopic total mesorectal excision for rectal cancer: integrating MR-based pelvimetry and peritoneal reflection.Frontiers in medicine · 2026Article
- Effect and influencing factors of early ileostomy closure 2-4 weeks on patients with rectal cancer.Frontiers in oncology · 2026Article
- The effect of neoadjuvant chemoradiotherapy on perioperative outcomes in rectal cancer patients following stoma reversal-a retrospective cohort analysis.Journal of gastrointestinal oncology · 2025Article
- Impact of statin therapy on postoperative outcomes following colorectal cancer surgery: A systematic review.World journal of gastrointestinal surgery · 2025Article
- Value of dynamic contrast-enhanced MRI in the diagnosis of acute radiation-induced rectal injury in patients with rectal cancer: A comparison with endoscopy.European journal of radiology open · 2025Article
- Article
- Surgery versus neoadjuvant chemoradiotherapy followed by surgery in locally advanced gastrointestinal tract cancers.Frontiers in oncology · 2025Article
- Pathological classification of chronic radiation-induced intestinal injury and its clinical implications.Gastroenterology report · 2025Article
- Role of dynamic contrast-enhanced MRI in predicting severe acute radiation-induced rectal injury in patients with rectal cancer.European radiology · 2024Article
- Fibrosis signature of anastomotic margins for predicting anastomotic stenosis in rectal cancer with neoadjuvant chemoradiotherapy and sphincter-preserving surgery.Gastroenterology report · 2024Article
- Predictors of Colorectal Resection and Primary Anastomosis outcome at Muhimbili National Hospital.The East African health research journal · 2024Article
- SOX combined with tislelizumab and low-dose radiation therapy for the neoadjuvant treatment of locally advanced gastric/gastroesophageal junction adenocarcinoma: study protocol for a prospective, multicenter, single-arm, phase Ib/II clinical trial.Frontiers in immunology · 2024Article
- Incidence and Risk Factors of Surgical Complications and Anastomotic Leakage After Transanal Total Mesorectal Excision for Middle and Low Rectal Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- The pattern of bowel dysfunction in patients with rectal cancer following the multimodal treatment: anorectal manometric measurements at before and after chemoradiation therapy, and postoperative 1 year.Annals of coloproctology · 2023Article
- Effects of Neoadjuvant Radiotherapy on Postoperative Complications in Rectal Cancer: A Meta-Analysis.Journal of oncology · 2022Article
- Post-operative anastomotic leakage and collagen changes in patients with rectal cancer undergoing neoadjuvant chemotherapy vs chemoradiotherapy.Gastroenterology report · 2022Article
- Can better surgical outcomes be obtained in the learning process of robotic rectal cancer surgery? A propensity score-matched comparison between learning phases.Surgical endoscopy · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies on anastomotic condition after rectal-cancer resection and its effect on anastomotic leakage (AL) are available up to now. This study aimed to investigate potential radiation-induced injury left on surgical margins of anterior resection after neoadjuvant chemoradiotherapy (nCRT) and its association with AL.
methodsWe retrospectively identified 161 consecutive patients who underwent anterior resection with nCRT, neoadjuvant chemotherapy without radiation (nCT) or no neoadjuvant therapy between 2014 and 2015. Tissue samples of resection margins were assessed using a specific histopathological score and microvessel density in submucosa. Propensity score matching was used to balance the baseline characteristics. Association between AL and histopathological features was analysed.
resultsAL occurred in 13 of 54 patients undergoing nCRT, 5 of 48 patients undergoing nCT and 7 of 59 patients without neoadjuvant therapy. Comparisons after matching showed median (range) histopathological scores as follows: 3 (0-8) vs 0 (0-3) vs 0 (0-2) for the proximal margin (
conclusionsSurgical margins of rectal-cancer resection are exposed to certain radiation-induced injury after nCRT. AL is associated with aggravated radiation damage on the proximal margin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.