Evidence map›Paper›PMID 30976397›Full record

ArticleClinical kidney journal2019

Use of machine-learning algorithms to determine features of systolic blood pressure variability that predict poor outcomes in hypertensive patients.

Ronilda C Lacson, Bowen Baker, Harini Suresh, Katherine Andriole, Peter Szolovits, Eduardo Lacson

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Survey and Evaluation of Hypertension Machine Learning Research.Journal of the American Heart Association · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Applications of artificial intelligence for hypertension management.Journal of clinical hypertension (Greenwich, Conn.) · 2021
    Review
  11. Article
  12. Article
  13. Review
  14. Clinical kidney journal · 2020
    Article
  15. Wearable health devices and personal area networks: can they improve outcomes in haemodialysis patients?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Review
  16. Article
  17. Machine learning and blood pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ronilda C LacsonBrigham and Women's Hospital, Boston MA, USA.ORCID 0000-0003-3300-1176
Bowen BakerDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Harini SureshDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Katherine AndrioleBrigham and Women's Hospital, Boston MA, USA.
Peter SzolovitsDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Eduardo LacsonDialysis Clinic, Inc., Nashville, TN, USA.
Massachusetts Institute of Technology · USBrigham and Women's Hospital · USTufts Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe re-analyzed data from the Systolic Blood Pressure Intervention Trial (SPRINT) trial to identify features of systolic blood pressure (SBP) variability that portend poor cardiovascular outcomes using a nonlinear machine-learning algorithm.

methodsWe included all patients who completed 1 year of the study without reaching any primary endpoint during the first year, specifically: myocardial infarction, other acute coronary syndromes, stroke, heart failure or death from a cardiovascular event (

resultsA total of 365 patients (4.1%) reached the combined primary outcome over 37 months of follow-up. The random forest classifier had an AUC of 0.71 on the testing set. The 10 most significant features selected in order of importance by the automated algorithm included the urine albumin/creatinine (CR) ratio, estimated glomerular filtration rate, age, serum CR, history of subclinical cardiovascular disease (CVD), cholesterol, a variable representing SBP signals using wavelet transformation, high-density lipoprotein, the 90th percentile of SBP and triglyceride level.

conclusionsWe successfully demonstrated use of random forest algorithm to define best prognostic longitudinal SBP representations. In addition to known risk factors for CVD, transformed variables for time series SBP measurements were found to be important in predicting poor cardiovascular outcomes and require further evaluation.

Indexed as

blood pressurecardiovascular diseasesheart diseasehypertensionmachine learning

Identifiers

PMID30976397
PMCPMC6452173
OpenAlexW2935806263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.