Evidence map›Paper›PMID 30976287›Full record

ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2019

Variability in total serum IgE over 1 year in severe asthmatics.

Renaud Louis, Charles Pilette, Olivier Michel, Alain Michils, Guy Brusselle, Antoine Poskin, Jan Van Schoor, Kris Denhaerynck, Stefaan Vancayzeele, Ivo Abraham and 1 more

Open access · goldAbstract read
In one paragraph

Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Clinical correlations with unmet social needs in critically ill children with asthma.The journal of allergy and clinical immunology. Global · 2025
    Article
  3. Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025
    Article
  4. Correlation between total IgE level and asthma symptom severity in hospitalized children.The journal of allergy and clinical immunology. Global · 2025
    Article
  5. Article
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  7. Review
  8. Article
  9. Article
  10. Article
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  13. Article
  14. Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

Renaud Louis1Service de Pneumologie-Allergologie, CHU Sart Tilman B35, 4000 Liege, Belgium.
Charles Pilette2Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium.
Olivier Michel3CHU Brugmann, Place A.Van Gehuchten 4, 1020 Brussels, Belgium.
Alain Michils4CUB Hôpital Erasme, Route de Lennik 808, 1070 Brussels, Belgium.
Guy Brusselle5UZ Gent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Antoine Poskin6Novartis Pharma, Medialaan 40, 1800 Vilvoorde, Belgium.
Jan Van Schoor6Novartis Pharma, Medialaan 40, 1800 Vilvoorde, Belgium.
Kris DenhaerynckMatrix45, LLC, 6159 West Sunset Road, Tucson, AZ 85743 USA.
Stefaan Vancayzeele6Novartis Pharma, Medialaan 40, 1800 Vilvoorde, Belgium.
Ivo AbrahamMatrix45, LLC, 6159 West Sunset Road, Tucson, AZ 85743 USA.
Sandra Gurdain6Novartis Pharma, Medialaan 40, 1800 Vilvoorde, Belgium.
Novartis (Belgium) · BECentre Hospitalier Universitaire Brugmann · BECliniques Universitaires Saint-Luc · BEDepartment of Biomedicine Basel · CHErasmus Hospital · BEGhent University Hospital · BEMatrix Research (United States) · USUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunoglobulin E (IgE) is the treatment target of omalizumab, a monoclonal antibody indicated in the treatment of severe allergic asthma. Long-term variability of serum total IgE (sIgE

methodsIn this prospective study, sIgE

resultsThe variation in sIgE

conclusionIn severe asthmatics, limited within-patient variability of sIgE

Indexed as

AsthmaIgEVariability

Identifiers

PMID30976287
PMCPMC6441212
OpenAlexW2943670034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.