Evidence map›Paper›PMID 30976283›Full record

ArticleMolecular syndromology2019

An FDA-Approved Drug Screen for Compounds Influencing Craniofacial Skeletal Development and Craniosynostosis.

Marian Seda, Maartje Geerlings, Peggy Lim, Jeshmi Jeyabalan-Srikaran, Ann-Christin Cichon, Peter J Scambler, Philip L Beales, Victor Hernandez-Hernandez, Andrew W Stoker, Dagan Jenkins

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular syndromology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Marian SedaGenetics and Genomic Medicine, UCL Institute of Child Health, London, UK.
Maartje GeerlingsGenetics and Genomic Medicine, UCL Institute of Child Health, London, UK.
Peggy LimGenetics and Genomic Medicine, UCL Institute of Child Health, London, UK.
Jeshmi Jeyabalan-SrikaranGenetics and Genomic Medicine, UCL Institute of Child Health, London, UK.
Ann-Christin CichonDevelopmental Biology and Cancer Programmes, UCL Institute of Child Health, London, UK.
Peter J ScamblerDevelopmental Biology and Cancer Programmes, UCL Institute of Child Health, London, UK.
Philip L BealesGenetics and Genomic Medicine, UCL Institute of Child Health, London, UK.
Victor Hernandez-HernandezGenetics and Genomic Medicine, UCL Institute of Child Health, London, UK.
Andrew W StokerDevelopmental Biology and Cancer Programmes, UCL Institute of Child Health, London, UK.
Dagan JenkinsGenetics and Genomic Medicine, UCL Institute of Child Health, London, UK.
University College London · GB

Funding

Medical Research Council MR/L009978/1
6 · The paper itself

Abstract

Neural crest stem/progenitor cells (NCSCs) populate a variety of tissues, and their dysregulation is implicated in several human diseases including craniosynostosis and neuroblastoma. We hypothesised that small molecules that inhibit NCSC induction or differentiation may represent potential therapeutically relevant drugs in these disorders. We screened 640 FDA-approved compounds currently in clinical use for other conditions to identify those which disrupt development of NCSC-derived skeletal elements that form the zebrafish jaw. In the primary screen, we used heterozygous transgenic

Indexed as

FDA-approved drug screenNeural crest stem/progenitor cellsSkeletal development

Identifiers

PMID30976283
PMCPMC6422125
OpenAlexW2886689208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.