ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2019
Dose-response evaluation of a copaiba-containing varnish against streptococcus mutans in vivo.
Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05308732 (Phase I Study of Multiple Ascending Dose, to Investigate the Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy), which is not on this map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase I Study of Multiple Ascending Dose, to Investigate the Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy
Who cites it
10 citing papers in PubMed.
- An Alternative Technique for Topical Application of Acidulated Phosphate Fluoride (APF) Gel: A Two-Years Double-Blind Randomization Clinical Trial (RCT).Medicina (Kaunas, Lithuania) · 2023Trial
- Efficacy ofInternational journal of dentistry · 2026Article
- Medicinal Plants Against Dental Caries: Research and Application of Their Antibacterial Properties.Plants (Basel, Switzerland) · 2025Review
- Fluoride Content, Availability, and Stability in a Propolis-Based Dentifrice.International journal of dentistry · 2025Article
- Anti-inflammatory and wound healing effect of Copaiba oleoresin on the oral cavity: A systematic review.Heliyon · 2022Review
- Salivary Fluoride Bioavailability after Brushing with Brazilian Red Propolis Dentifrice: A Clinical Study.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Clinical and Antimicrobial Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Review
- Antimicrobial Efficacy of Propolis-Containing Varnish in Children: A Randomized and Double-Blind Clinical Trial.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Biomarkers of Orthodontic Patients After Use of 1% Brazilian Red Propolis Toothpaste: A Randomized Clinical Study.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDental caries is the most prevalent disease in humans and its incidence is particularly high during childhood. The use of medicinal plants is a common practice in Brazil.
objectiveTo evaluate the optimal antimicrobial concentration of
methodsTwenty-four children, caries-free, aged until 6 years old, were selected to participate in this study. The varnish was applied to the occlusal surfaces of all deciduous molars. The antimicrobial activity was analyzed in saliva, whose collection was conducted in two phases: before applying the copaiba varnish and after use to verify the instantaneous effectiveness of
resultsComparisons between different times within the same dilution were carried out by repeated measures analysis of variance (ANOVA) associated with Tukey's multiple comparisons test. Comparisons of conditions prior to and after treatment were performed using the
conclusionCopaiba oil-resin, in the form of dental varnish, has antimicrobial activity against
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