ArticleJournal of ginseng research2019
Ameliorative effect of black ginseng extract against oxidative stress-induced cellular damages in mouse hepatocytes.
Article in Journal of ginseng research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Anticancer effects of black ginseng extract on human gastric cancer in a xenograft mouse model.American journal of translational research · 2026Article
- Targeting the DNA damage response (DDR) of cancer cells with natural compounds derived fromJournal of ginseng research · 2025Review
- Chinese medicine in the treatment of non-alcoholic fatty liver disease based on network pharmacology: a review.Frontiers in pharmacology · 2024Review
- Changes in the chemical composition and medicinal effects of black ginseng during processing.Frontiers in pharmacology · 2024Article
- Article
- Antioxidant Phenylpropanoid Glycosides fromPlants (Basel, Switzerland) · 2021Article
- Plants Used as Antihypertensive.Natural products and bioprospecting · 2021Review
- Metabolic Changes in Serum Metabolome of Beagle Dogs Fed Black Ginseng.Metabolites · 2020Article
- [Effect of hot water extract of Korean ginseng on neuroblastoma cell parthanatos].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?Biomolecules · 2020Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative stress induces the production of reactive oxygen species (ROS), which play important causative roles in various pathological conditions. Black ginseng (BG), a type of steam-processed ginseng, has drawn significant attention due to its biological activity, and is more potent than white ginseng (WG) or red ginseng (RG).
methodsWe evaluated the protective effects of BG extract (BGE) against oxidative stress-induced cellular damage, in comparison with WG extract (WGE) and RG extract (RGE) in a cell culture model. Ethanolic extracts of WG, RG, and BG were used to evaluate ginsenoside profiles, total polyphenols, flavonoid contents, and antioxidant activity. Using AML-12 cells treated with H
resultsBGE exhibited significantly enhanced antioxidant potential, as well as total flavonoid and polyphenol contents. ATP levels were significantly higher in BGE-treated cells than in control; ROS generation and glutathione disulfide levels were lower but glutathione (GSH) and NADPH levels were higher in BGE-treated cells than in other groups. Pretreatment with BGE inhibited apoptosis and therefore protected cells from oxidative stress-induced cellular damage, probably through ROS scavenging.
conclusionCollectively, our results demonstrate that BGE protects AML-12 cells from oxidative stress-induced cellular damages more effectively than WGE or RGE, through ROS scavenging, maintenance of redox status, and activation of the antioxidant defense system.
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