Evidence map›Paper›PMID 30976104›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2019

PD-1 (PDCD1) promoter methylation in Merkel cell carcinoma: prognostic relevance and relationship with clinico-pathological parameters.

Costantino Ricci, Luca Morandi, Alberto Righi, Dino Gibertoni, Francesca Maletta, Francesca Ambrosi, Claudio Agostinelli, Silvia Uccella, Silvia Asioli, Fausto Sessa and 5 more

Open access · bronzeAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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  16. Role of Virus-Induced Host Cell Epigenetic Changes in Cancer.International journal of molecular sciences · 2021
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  19. Personalized treatment concepts in extraocular cancer.Advances in ophthalmology practice and research
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Costantino RicciDepartment of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology "M. Malpighi", Bellaria Hospital, Bologna, Italy.ORCID http://orcid.org/0000-0001-7254-4195
Luca MorandiDepartment of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology "M. Malpighi", Bellaria Hospital, Bologna, Italy.ORCID http://orcid.org/0000-0002-3810-9760
Alberto RighiDepartment of Pathology, Rizzoli Institute, Bologna, Italy.
Dino GibertoniDepartment of Biomedical and Neuromotor Sciences, Unit of Hygiene and Biostatistics, University of Bologna, Bologna, Italy.
Francesca MalettaDepartment of Oncology, University of Turin, Turin, Italy.
Francesca AmbrosiDepartment of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology "M. Malpighi", Bellaria Hospital, Bologna, Italy.
Claudio AgostinelliDepartment of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy.
Silvia UccellaUnit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Silvia AsioliDepartment of Pathology, Morgagni-Pierantoni Hospital, 47121, Forlì, Italy.
Fausto SessaUnit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Maria PellilliUnit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Roberta MaraglianoUnit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Stefano La RosaService of Clinical Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Mauro Giulio PapottiDepartment of Oncology, University of Turin, Turin, Italy.
Sofia AsioliDepartment of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology "M. Malpighi", Bellaria Hospital, Bologna, Italy. sofia.asioli3@unibo.it.ORCID http://orcid.org/0000-0003-3672-8178
University of Insubria · ITOspedale Bellaria · ITOspedale G.B. Morgagni - L.Pierantoni · ITUniversity of Bologna · ITUniversity of Turin · ITIstituto Ortopedico Rizzoli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Merkel cell carcinoma is an aggressive neuroendocrine skin tumor, for which several non-conclusive prognostic factors of adverse clinical behavior have been reported. As promoter methylation of the immune checkpoint receptor CD279/PD-1/PDCD1(mPDCD1) has been shown to be a prognostic factor in different cancers, we investigated its role in Merkel cell carcinoma. mPDCD1was assessed retrospectively in a cohort of 69 Merkel cell carcinoma patients from the University of Bologna, University of Turin and University of Insubria. Kaplan-Meier curves and log-rank tests were calculated for all variables. To assess the influence of mPDCD1, the Cox proportional hazards model and different Royston-Parmar models were evaluated. High PDCD1 methylation (mPDCD1

Indexed as

AgedAged, 80 and overCarcinoma, Merkel CellDNA MethylationFemaleHumansMaleMiddle AgedPrognosisProgrammed Cell Death 1 ReceptorPromoter Regions, GeneticSkin NeoplasmsPDCD1 protein, humanProgrammed Cell Death 1 Receptor

Identifiers

PMID30976104
OpenAlexW2939084812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.