Evidence map›Paper›PMID 30976087›Full record

ReviewMucosal immunology2019

Microbes, metabolites, and the gut-lung axis.

Anh Thu Dang, Benjamin J Marsland

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Mucosal immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 637 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
637citing papers in PubMed, 8 pooled it
32.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

637 citing papers in PubMed, 8 syntheses or guidelines pooled it, 955 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025
    Pooled it
  8. Pooled it
  9. Trial
  10. Efficacy ofFrontiers in nutrition · 2026
    Trial
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  12. Review
  13. Review
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  15. iMeta · 2026
    Article
  16. Review
  17. Article
  18. Article
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  20. Review

577 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anh Thu DangDepartment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.
Benjamin J MarslandDepartment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia. benjamin.marsland@monash.edu.
Monash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microbiota plays an essential role in the education, development, and function of the immune system, both locally and systemically. Emerging experimental and epidemiological evidence highlights a crucial cross-talk between the intestinal microbiota and the lungs, termed the 'gut-lung axis'. Changes in the constituents of the gut microbiome, through either diet, disease or medical interventions (such as antibiotics) is linked with altered immune responses and homeostasis in the airways. The importance of the gut-lung axis has become more evident following the identification of several gut microbe-derived components and metabolites, such as short-chain fatty acids (SCFAs), as key mediators for setting the tone of the immune system. Recent studies have supported a role for SCFAs in influencing hematopoietic precursors in the bone marrow-a major site of innate and adaptive immune cell development. Here, we review the current understanding of host-microbe cross-talk along the gut-lung axis. We highlight the importance of SCFAs in shaping and promoting bone marrow hematopoiesis to resolve airway inflammation and to support a healthy homeostasis.

Indexed as

Energy MetabolismHomeostasisMicrobiotaAnimalsBone MarrowDysbiosisFatty Acids, VolatileGastrointestinal MicrobiomeGastrointestinal TractHematopoiesisHumansImmunomodulationIntestinal MucosaLungFatty Acids, Volatile

Identifiers

PMID30976087
OpenAlexW2936757566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.