ArticleScientific reports2019
Enhancing cancer cell adhesion with clay nanoparticles for countering metastasis.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Comparative inhibitory effects of zeolite, sepiolite, and kaolinite on A549 lung cancer cells.PloS one · 2026Article
- Aegle marmelos-mediated zinc oxide nanoparticles for mosquito control, cancer therapy, and antibacterial applications.Bioprocess and biosystems engineering · 2025Article
- Review
- Determination ofPlants (Basel, Switzerland) · 2024Article
- Evaluation of biogenically synthesized MgO NPs anticancer activity against breast cancer cells.Saudi journal of biological sciences · 2024Article
- FN1 mediated activation of aspartate metabolism promotes the progression of triple-negative and luminal a breast cancer.Breast cancer research and treatment · 2023Article
- Recent Advances in Kaolinite Nanoclay as Drug Carrier for Bioapplications: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- The extracellular matrix mechanics in the vasculature.Nature cardiovascular research · 2023Review
- Investigation of Aggregation and Disaggregation of Self-Assembling Nano-Sized Clusters Consisting of Individual Iron Oxide Nanoparticles upon Interaction with HEWL Protein Molecules.Nanomaterials (Basel, Switzerland) · 2022Article
- Nano-Clays for Cancer Therapy: State-of-the Art and Future Perspectives.Journal of personalized medicine · 2022Review
- Clay Minerals as Bioink Ingredients for 3D Printing and 3D Bioprinting: Application in Tissue Engineering and Regenerative Medicine.Pharmaceutics · 2021Review
- Pancreatic Lineage Specifier PDX1 Increases Adhesion and Decreases Motility of Cancer Cells.Cancers · 2021Article
- Nano-bio surface interactions, cellular internalisation in cancer cells and e-data portals of nanomaterials: A review.IET nanobiotechnology · 2021Review
- Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition: Interfering with the crosstalk between "seed and soil".Acta pharmaceutica Sinica. B · 2021Review
- Linear and nonlinear investigations for the adsorption of paracetamol and metformin from water on acid-treated clay.Scientific reports · 2021Article
- Melanoma treatment via non-specific adhesion of cancer cells using charged nano-clays in pre-clinical studies.Scientific reports · 2021Article
- Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signaling.Scientific reports · 2020Article
- Anti-Oxidant, Anti-Hemolytic Effects of Crataegus aronia Leaves and Its Anti- Proliferative Effect Enhance Cisplatin Cytotoxicity in A549 Human Lung Cancer Cell Line.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Nano-clays as Potential Pseudo-antibodies for COVID-19.Nanoscale research letters · 2020Article
- Soft Actuated Hybrid Hydrogel with Bioinspired Complexity to Control Mechanical Flexure Behavior for Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer metastasis results from the suppression of adhesion between cancer cells and the extracellular matrix, causing their migration from the primary tumor location and the subsequent formation of tumors in distant organs. This study demonstrates the potential use of nano-sized clay mineral particles to modulate adhesions between tumor cells and with the surrounding extracellular matrix. Atomic force microscopy studies of live cell cultures reveal a significant increase in adhesion between tumor cells and their environment after treatment with different types of electrically charged clay nanoparticles. The enhancement of adhesion among cancer cells was further confirmed through scratch type of wound healing assay studies. To provide insight into the adhesion mechanisms introduced by the clay nanoparticles, we performed a molecular-level computer simulation of cell adhesions in the presence and absence of the nanoparticles. Strong van der Waals and electrostatic attractions modelled in the molecular simulations result in an increase in the cohesive energy density of these environments when treated with clay crystallites. The increase in the cohesive energy density after the sorption of clay crystallites on cell-cell and cell-extracellular matrix complexes lends weight to our strategy of using clay nanoparticles for the restoration of adhesion among cancer cells and prevention of metastasis.
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