ArticleScientific reports2019
Behavior of mice aboard the International Space Station.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glucocorticoids in relation to behavior, morphology, and physiology as proxy indicators for the assessment of animal welfare. A systematic mapping review.Frontiers in veterinary science · 2022Pooled it
- Assessment of auditory and vestibular function and gene therapy in the Snell's waltzer mouse model of human deafness and balance dysfunction.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Automated behavioral segmentation and markerless pose tracking of mice during spaceflight.bioRxiv : the preprint server for biology · 2026Article
- Mechatronics Design of a Clinostat Agriculture Space System for Biomimetic Phyto-Growth in Microgravity (Phyto-G) and 3D-Motion Computer Simulation on Hydroponic Environment.Biomimetics (Basel, Switzerland) · 2026Article
- The effect of spaceflight on tissues of the spinal column.Bone reports · 2026Review
- Simulated microgravity affects neuronal synaptic plasticity by regulating microglial pro-inflammatory activation.NPJ microgravity · 2026Article
- Structure-Aware Multi-Animal Pose Estimation for Space Model Organism Behavior Analysis.Animals : an open access journal from MDPI · 2025Article
- C/EBP-β/MeCP2/Wnt Axis Participates in the Testicular Injury in Rats Under Simulated Microgravity Conditions.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Brains in space: impact of microgravity and cosmic radiation on the CNS during space exploration.Nature reviews. Neuroscience · 2025Review
- Transcriptomic Changes in Mouse Lung Tissue after a Long-Term Space Flight.Bulletin of experimental biology and medicine · 2025Article
- The utility of animal models to inform the next generation of human space exploration.NPJ microgravity · 2025Review
- Article
- Dynamic Changes in Hindlimb Motor Cortex Neurons during Simulated Weightlessness Revealed by Miniature 2-Photon Microscopy.Research (Washington, D.C.) · 2025Article
- 37-Day microgravity exposure in 16-Week female C57BL/6J mice is associated with bone loss specific to weight-bearing skeletal sites.PloS one · 2025Article
- Exploring the Idea of Human Reproduction in Space: A Potential Area for Future Research.Cureus · 2024Review
- Heart-on-a-Chip at the final frontier.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Profiling muscle transcriptome in mice exposed to microgravity using gene set enrichment analysis.NPJ microgravity · 2024Article
- Exploiting the Unique Biology ofAstrobiology · 2024Article
- Microglial activation in spaceflight and microgravity: potential risk of cognitive dysfunction and poor neural health.Frontiers in cellular neuroscience · 2024Review
- Microgravity's effects on miRNA-mRNA regulatory networks in a mouse model of segmental bone defects.PloS one · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interest in space habitation has grown dramatically with planning underway for the first human transit to Mars. Despite a robust history of domestic and international spaceflight research, understanding behavioral adaptation to the space environment for extended durations is scant. Here we report the first detailed behavioral analysis of mice flown in the NASA Rodent Habitat on the International Space Station (ISS). Following 4-day transit from Earth to ISS, video images were acquired on orbit from 16- and 32-week-old female mice. Spaceflown mice engaged in a full range of species-typical behaviors. Physical activity was greater in younger flight mice as compared to identically-housed ground controls, and followed the circadian cycle. Within 7-10 days after launch, younger (but not older), mice began to exhibit distinctive circling or 'race-tracking' behavior that evolved into coordinated group activity. Organized group circling behavior unique to spaceflight may represent stereotyped motor behavior, rewarding effects of physical exercise, or vestibular sensation produced via self-motion. Affording mice the opportunity to grab and run in the RH resembles physical activities that the crew participate in routinely. Our approach yields a useful analog for better understanding human responses to spaceflight, providing the opportunity to assess how physical movement influences responses to microgravity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.