ArticleNature communications2019
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
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Who cites it
61 citing papers in PubMed, 90 citations in OpenAlex.
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- IDPForge: Deep Learning of Proteins with Global and Local Regions of Disorder.bioRxiv : the preprint server for biology · 2026Article
- Label-free optical observation of disordered-to-ordered transitions in single intrinsically disordered proteins.Npj biosensing · 2026Article
- Targeting protein disorder: the next hurdle in drug discovery.Nature reviews. Drug discovery · 2025Review
- Deciphering the Mechanisms Underlying the Antitumor Effects of Eucalyptus Essential Oil and Its Component 3-Cyclohexene-1-Methanol Against Human Colon Cancer Cells.International journal of molecular sciences · 2025Article
- Time-Resolved Fluorescence Anisotropy from Single Molecules for Characterizing Local Flexibility in Biomolecules.Journal of visualized experiments : JoVE · 2025Article
- Multi-omics analysis identifies OSGEPL1 as an oncogene in hepatocellular carcinoma.Discover oncology · 2025Article
- p27Cells · 2025Article
- Regulatory role of E3 ubiquitin ligases in multiple myeloma: from molecular mechanisms to therapeutic strategies.Frontiers in cell and developmental biology · 2025Review
- SRC is a potential target of Arctigenin in treating triple-negative breast cancer: based on machine learning algorithms, molecular modeling andFrontiers in molecular biosciences · 2025Article
- Graph-Based Spatial Proximity of Super-Resolved Protein-Protein Interactions Predicts Cancer Drug Responses in Single Cells.Cellular and molecular bioengineering · 2024Article
- DNA controls the dimerization of the human FoxP1 forkhead domain.Cell reports. Physical science · 2024Article
- High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.Nature communications · 2024Article
- High-throughput assay exploiting disorder-to-order conformational switches: application to the proteasomal Rpn10:E6AP complex.Chemical science · 2024Article
- Novel benzo chromene derivatives: design, synthesis, molecular docking, cell cycle arrest, and apoptosis induction in human acute myeloid leukemia HL-60 cells.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- The Onset of Molecule-Spanning Dynamics in Heat Shock Protein Hsp90.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Nuclear magnetic resonance/single molecule fluorescence combinations to study dynamic protein systems.Current opinion in structural biology · 2023Review
- DNA facilitates heterodimerization between human transcription factors FoxP1 and FoxP2 by increasing their conformational flexibility.iScience · 2023Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 3 institutions in 4 countries.
Maksym TsytlonokVIB Center for Structural Biology, Vrije Universiteit Brussel, Pleinlaan, 2 1050, Brussels, Belgium.
Hugo SanabriaDepartment of Physics and Astronomy, Clemson University, Clemson, SC, 29634, USA.ORCID http://orcid.org/0000-0001-7068-6827
Yuefeng WangDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.
Suren FelekyanLehrstuhl für Molekulare Physikalische Chemie, Heinrich-Heine-Universität, 40225, Düsseldorf, Germany.
Katherina HemmenLehrstuhl für Molekulare Physikalische Chemie, Heinrich-Heine-Universität, 40225, Düsseldorf, Germany.
Aaron H PhillipsDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.
Mi-Kyung YunDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.
M Brett WaddellDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.
Cheon-Gil ParkDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.
Sivaraja VaithiyalingamDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.
Luigi IconaruDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.
Stephen W WhiteDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.ORCID http://orcid.org/0000-0001-8188-5944
Peter TompaVIB Center for Structural Biology, Vrije Universiteit Brussel, Pleinlaan, 2 1050, Brussels, Belgium. tompa@enzim.hu.
Claus A M SeidelLehrstuhl für Molekulare Physikalische Chemie, Heinrich-Heine-Universität, 40225, Düsseldorf, Germany. cseidel@hhu.de.ORCID http://orcid.org/0000-0002-5171-149X
Richard KriwackiDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA. richard.kriwacki@stjude.org.ORCID http://orcid.org/0000-0002-9798-6018
St. Jude Children's Research Hospital · USHeinrich Heine University Düsseldorf · DEVrije Universiteit Brussel · BE
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MTissue Structural and Neural Remodeling in Human Sacroiliac JointP20GM121342 · NIGMS · CLEMSON UNIVERSITY · PI Hai Yao · 2018 to 2026
$24.7MStructural Determinants in Cell Growth Control by p21 and p27R01CA082491 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KRIWACKI, RICHARD W · 2001 to 2011
$2.7MUnderstanding the Structural Mechanism of Puma-induced ApoptosisR01GM083159 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KRIWACKI, RICHARD W · 2009 to 2012
$1.3MNCI NIH HHS P30 CA021765NCI NIH HHS R01 CA082491NIGMS NIH HHS P20 GM121342NIGMS NIH HHS R01 GM083159NIH HHS P20GM121342NIH HHS R01MH08192311
Abstract
p27
Indexed as
Cell DivisionCrystallography, X-RayCyclin ACyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p27Fusion Proteins, bcr-ablMolecular Dynamics SimulationMutagenesis, Site-DirectedPhosphorylationProtein BindingProtein Processing, Post-TranslationalProtein Structure, TertiaryProteolysisRecombinant ProteinsSignal Transductionsrc-Family KinasesCDK2 protein, humanCDKN1B protein, humanCyclin ACyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p27Fusion Proteins, bcr-ablRecombinant Proteinssrc-Family KinasesThreonineTyrosine
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.