Evidence map›Paper›PMID 30975979›Full record

ArticleCell death & disease2019

The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors.

Maria Pia Abruzzese, Maria Teresa Bilotta, Cinzia Fionda, Alessandra Zingoni, Alessandra Soriani, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Rosa Molfetta, Rossella Paolini, Angela Santoni and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Maria Pia AbruzzeseDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Maria Teresa BilottaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Cinzia FiondaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Alessandra ZingoniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Alessandra SorianiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-5461-9026
Maria Teresa PetrucciDivision of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy.
Maria Rosaria RicciardiHematology, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Rosa MolfettaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Rossella PaoliniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Angela SantoniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy. angela.santoni@uniroma1.it.
Marco CippitelliDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy. marco.cippitelli@uniroma1.it.ORCID http://orcid.org/0000-0002-9620-538X
Sapienza University of Rome · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcription factor Myeloid Ecotropic Insertion Site 2 (MEIS2) has been identified as a cellular substrate of the E3-ubiquitin ligase complex CRL4-cereblon (

Indexed as

Adaptor Proteins, Signal TransducingAntineoplastic AgentsApoptosisAzepinesBortezomibCell Line, TumorCell ProliferationCell SurvivalGenes, HomeoboxHomeodomain ProteinsHumansImmunomodulationMultiple MyelomaProtein DomainsTranscription FactorsTriazolesAdaptor Proteins, Signal TransducingAntineoplastic AgentsAzepinesBortezomibCRBN protein, humanHomeodomain Proteins(+)-JQ1 compoundMEIS2 protein, humanTranscription FactorsTriazolesUbiquitin-Protein Ligases

Identifiers

PMID30975979
PMCPMC6459881
OpenAlexW2937857851

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.