ArticleThe Journal of biological chemistry2019
Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function.
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Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- ACSL4 in Alzheimer's disease: Pathogenetic mechanisms and potential therapeutic targets.Genes & diseases · 2026Review
- Acyl-CoA Synthetase 5 Knockout and Inhibitors Protect Against Diet-Induced Obesity in Mice by Activating the Ileal Brake.Journal of the Endocrine Society · 2026Article
- Effects of moderate intensity exercise on liver metabolism in mice based on multi-omics analysis.Scientific reports · 2024Article
- ACSL1 improves pulmonary fibrosis by reducing mitochondrial damage and activating PINK1/Parkin mediated mitophagy.Scientific reports · 2024Article
- Unmodulated 40 Hz Stimulation as a Therapeutic Strategy for Aging: Improvements in Metabolism, Frailty, and Cognitive Function in Senescence-Accelerated Prone 10 Mice.Biomolecules · 2024Article
- shRNA-mediated down-regulation of Acsl1 reverses skeletal muscle insulin resistance in obese C57BL6/J mice.PloS one · 2024Article
- Exploration of molecular biomarkers in ankylosing spondylitis transcriptomics.Frontiers in immunology · 2024Article
- Role ofJournal of microbiology and biotechnology · 2023Article
- Calorie Restriction Rescues Mitochondrial Dysfunction in Adck2-Deficient Skeletal Muscle.Frontiers in physiology · 2022Article
- Novel Insight Into the Role ofFrontiers in genetics · 2022Article
- An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial β-Oxidation in C2C12 Myotubes.Molecules and cells · 2021Article
- Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity.Frontiers in endocrinology · 2021Article
- Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation.Cell reports · 2020Article
- Long-chain acyl-CoA synthetase-1 mediates the palmitic acid-induced inflammatory response in human aortic endothelial cells.American journal of physiology. Endocrinology and metabolism · 2020Article
- Acyl-CoA synthetases as regulators of brain phospholipid acyl-chain diversity.Prostaglandins, leukotrienes, and essential fatty acids · 2020Review
- Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Liyang ZhaoFrom the Departments of Nutrition and.
Florencia PascualFrom the Departments of Nutrition and.
Lawrence BacudioFrom the Departments of Nutrition and.
Amanda L SuchanekFrom the Departments of Nutrition and.
Pamela A YoungFrom the Departments of Nutrition and.
Lei O LiFrom the Departments of Nutrition and.
Sarah A Martinthe Department of Molecular Genetics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, and.
Joao-Paulo Camporezthe Departments of Internal Medicine and.
Rachel J Perrythe Departments of Internal Medicine and.
Gerald I Shulmanthe Departments of Internal Medicine and.ORCID 0000-0003-1529-5668
Eric L KlettMedicine, University of North Carolina, Chapel Hill, North Carolina 27599.
Rosalind A ColemanFrom the Departments of Nutrition and rcoleman@unc.edu.ORCID 0000-0003-4379-3824
University of North Carolina at Chapel Hill · USYale University · USThe University of Texas Southwestern Medical Center · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6MMETABOLISM OF GLYCEROLIPIDS IN LIVERR01DK056598 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COLEMAN, ROSALIND ANNE · 1999 to 2016
$5.0MAcyl-CoA Synthetase: Structure, Function and RegulationR01DK059935 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COLEMAN, ROSALIND ANNE · 2002 to 2015
$4.7MLipid Metabolism and Beta-cell FunctionR01DK107481 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KLETT, ERIC · 2016 to 2020
$1.7MGlucagon Regulation of Hepatic Mitochondrial Activity and Glucose Metabolism by InsP3R-1R01DK116774 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2018 to 2021
$1.7MRegulation of tumor growth and metabolism by hyperinsulinemiaR00CA215315 · NCI · YALE UNIVERSITY · PI PERRY, RACHEL JAMISON · 2018 to 2020
$689kRegulation of tumor growth and metabolism by hyperinsulinemiaK99CA215315 · NCI · YALE UNIVERSITY · PI PERRY, RACHEL JAMISON · 2017 to 2018
$297kGlycerolipid synthesis in liverR56DK056598 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COLEMAN, ROSALIND ANNE · 2017 to 2017
$228kNCATS NIH HHS UL1 TR001863NCI NIH HHS K99 CA215315NCI NIH HHS R00 CA215315NIDDK NIH HHS P30 DK045735NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK056598NIDDK NIH HHS R01 DK059935NIDDK NIH HHS R01 DK107481NIDDK NIH HHS R01 DK116774NIDDK NIH HHS R56 DK056598
Abstract
Loss of long-chain acyl-CoA synthetase isoform-1 (ACSL1) in mouse skeletal muscle (
Indexed as
Amino AcidsAnimalsApoptosisAspartate AminotransferasesCaspase 3Coenzyme A LigasesCreatine KinaseFatty AcidsLipid MetabolismLong-Chain-Fatty-Acid-CoA LigaseMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, KnockoutMitochondriaMuscle, SkeletalAmino AcidsAspartate AminotransferasesCaspase 3Coenzyme A LigasesCreatine KinaseFatty AcidsLong-Chain-Fatty-Acid-CoA LigaseMechanistic Target of Rapamycin Complex 1acyl-CoA synthetase isoform-1 (ACSL1)amino acidfatty acid oxidationgastrocnemiusmuscle regenerationmyopathyprotein synthesisskeletal musclesoleus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.