Evidence map›Paper›PMID 30975899›Full record

ArticleThe Journal of biological chemistry2019

Slow extension of the invading DNA strand in a D-loop formed by RecA-mediated homologous recombination may enhance recognition of DNA homology.

Daniel Lu, Claudia Danilowicz, Tommy F Tashjian, Chantal Prévost, Veronica G Godoy, Mara Prentiss

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Chromosome topology gates productive RecA homology search.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Daniel LuDepartment of Physics, Harvard University, Cambridge, Massachusetts 02138.
Claudia DanilowiczDepartment of Physics, Harvard University, Cambridge, Massachusetts 02138.
Tommy F TashjianDepartment of Biology, Northeastern University, Boston, Massachusetts 02115.
Chantal PrévostLaboratoire de Biochimie Théorique, CNRS UMR 9080, Institut de Biologie Physico-chimique (IBPC), Paris 75005, France.
Veronica G GodoyDepartment of Biology, Northeastern University, Boston, Massachusetts 02115.
Mara PrentissDepartment of Physics, Harvard University, Cambridge, Massachusetts 02138. Electronic address: prentiss@fas.harvard.edu.
Harvard University · USNortheastern University · USCentre National de la Recherche Scientifique · FRHarvard University Press · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA recombination resulting from RecA-mediated strand exchange aided by RecBCD proteins often enables accurate repair of DNA double-strand breaks. However, the process of recombinational repair between short DNA regions of accidental similarity can lead to fatal genomic rearrangements. Previous studies have probed how effectively RecA discriminates against interactions involving a short similar sequence that is embedded in otherwise dissimilar sequences but have not yielded fully conclusive results. Here, we present results of

Indexed as

Homologous RecombinationDNA, BacterialDNA-Binding ProteinsDNA ProbesEscherichia coliEscherichia coli ProteinsRec A RecombinasesDNA, BacterialDNA-Binding ProteinsDNA ProbesEscherichia coli ProteinsrecA protein, E coliRec A RecombinasescooperativityDNA damageDNA polymeraseDNA recombinationdouble-strand break (DSB)fluorescence resonance energy transfer (FRET)heteroduplex formationmolecular dynamicsRecAstrand displacement synthesis

Identifiers

PMID30975899
PMCPMC6544866
OpenAlexW2937685376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.