Evidence map›Paper›PMID 30975892›Full record

ArticleThe Journal of experimental medicine2019

The Notch signaling pathway promotes basophil responses during helminth-induced type 2 inflammation.

Lauren M Webb, Oyebola O Oyesola, Simon P Früh, Elena Kamynina, Katherine M Still, Ravi K Patel, Seth A Peng, Rebecca L Cubitt, Andrew Grimson, Jennifer K Grenier and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 38 citations in OpenAlex.

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  15. iScience · 2022
    Article
  16. Review
  17. Review
  18. Basophils from allergy to cancer.Frontiers in immunology · 2022
    Review
  19. Basophils as a potential therapeutic target in cancer.Journal of Zhejiang University. Science. B · 2021
    Review
  20. The Role of CD4International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Lauren M WebbBaker Institute for Animal Health and Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY.ORCID 0000-0002-1903-7570
Oyebola O Oyesola *Baker Institute for Animal Health and Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY.
Simon P Früh *Baker Institute for Animal Health and Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY.ORCID 0000-0002-4757-8315
Elena KamyninaBaker Institute for Animal Health and Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY.
Katherine M StillCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA.
Ravi K PatelDepartment of Molecular Biology and Genetics, College of Arts and Sciences, Cornell University, Ithaca, NY.
Seth A PengBaker Institute for Animal Health and Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY.
Rebecca L CubittBaker Institute for Animal Health and Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY.
Andrew GrimsonDepartment of Molecular Biology and Genetics, College of Arts and Sciences, Cornell University, Ithaca, NY.
Jennifer K GrenierRNA Sequencing Core, Center for Reproductive Genomics, and Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY.
Tajie H HarrisCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA.
Charles G DankoBaker Institute for Animal Health and Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY.
Elia D Tait WojnoBaker Institute for Animal Health and Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY elia.taitwojno@cornell.edu.ORCID 0000-0003-2822-296X
Cornell University · USUniversity of Virginia · US

Funding

The Notch Signaling Pathway Regulates Basophil Responses During Helminth InfectionR01AI132708 · NIAID · UNIVERSITY OF WASHINGTON · PI TAIT WOJNO, ELIA D · 2017 to 2021
$2.1M
Mapping RNA polymerase in tissue samples with ChRO-seq.R01HG009309 · NHGRI · CORNELL UNIVERSITY · PI DANKO, CHARLES GRAHE · 2017 to 2021
$1.9M
Regulatory T cell responses in T. gondii infection of the brainR01NS091067 · NINDS · UNIVERSITY OF VIRGINIA · PI HARRIS, TAJIE H. · 2015 to 2019
$1.8M
Myeloid cell control of CNS infectionR56NS106028 · NINDS · UNIVERSITY OF VIRGINIA · PI HARRIS, TAJIE H. · 2019 to 2019
$399k
Prostaglandin regulation of type 2 inflammationK22AI116729 · NIAID · CORNELL UNIVERSITY · PI TAIT WOJNO, ELIA D · 2016 to 2017
$267k
NHGRI NIH HHS R01 HG009309NIAID NIH HHS K22 AI116729NIAID NIH HHS R01 AI132708NINDS NIH HHS R01 NS091067NINDS NIH HHS R56 NS106028
6 · The paper itself

Abstract

Type 2 inflammation drives the clearance of gastrointestinal helminth parasites, which infect over two billion people worldwide. Basophils are innate immune cells that support host-protective type 2 inflammation during murine infection with the helminth

Indexed as

Signal TransductionAnimalsBasophilsCecumFemaleGene Expression RegulationInflammationInterleukinsMaleMice, Inbred C57BLReceptors, NotchTrichurisUp-RegulationInterleukinsReceptors, Notch

Identifiers

PMID30975892
PMCPMC6547860
OpenAlexW2940402084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.