ArticleGenetics2019
Genetic Variation for Ontogenetic Shifts in Metabolism Underlies Physiological Homeostasis in
Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Pervasive effects ofbioRxiv : the preprint server for biology · 2026Article
- The "fire of life cycles": age-specific metabolic scaling within and among species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Review
- Stage-resolved transcriptomic profiling ofFrontiers in insect science · 2025Article
- Interactive effects of intrinsic and extrinsic factors on metabolic rate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A new mechanistic model for individual growth applied to insects under ad libitum conditions.PloS one · 2024Article
- Review
- Variable metabolic scaling breaks the law: from 'Newtonian' to 'Darwinian' approaches.Proceedings. Biological sciences · 2022Article
- How Metabolic Rate Relates to Cell Size.Biology · 2022Review
- Article
- Mitonuclear interactions alter sex-specific longevity in a species without sex chromosomes.Proceedings. Biological sciences · 2021Article
- A high-throughput method to quantify feeding rates in aquatic organisms: A case study withEcology and evolution · 2020Article
- Article
- Sex-specific effects of mitochondrial haplotype on metabolic rate inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Review
- Temperature-Sensitive Reproduction and the Physiological and Evolutionary Potential for Mother's Curse.Integrative and comparative biology · 2019Article
- Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism duringDevelopment (Cambridge, England) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organismal physiology emerges from metabolic pathways and subcellular structures like the mitochondria that can vary across development and among individuals. Here, we tested whether genetic variation at one level of physiology can be buffered at higher levels of biological organization during development by the inherent capacity for homeostasis in physiological systems. We found that the fundamental scaling relationship between mass and metabolic rate, as well as the oxidative capacity per mitochondria, changed significantly across development in the fruit fly
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.