Evidence map›Paper›PMID 30975748›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Jonathon L Baker, Erik L Hendrickson, Xiaoyu Tang, Renate Lux, Xuesong He, Anna Edlund, Jeffrey S McLean, Wenyuan Shi

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. General Overview ofBiology · 2024
    Review
  13. Defining a metagenomic threshold for detecting low abundances ofFrontiers in cellular and infection microbiology · 2024
    Article
  14. Review
  15. A chronic stress-induced microbiome perturbation, highly enriched inInternational journal of medical sciences · 2024
    Article
  16. Article
  17. Article
  18. Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonathon L BakerGenomic Medicine Group, J. Craig Venter Institute, La Jolla, CA 92037.ORCID 0000-0001-5378-322X
Erik L HendricksonDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, WA 98195.
Xiaoyu TangGenomic Medicine Group, J. Craig Venter Institute, La Jolla, CA 92037.ORCID 0000-0002-7855-5984
Renate LuxDepartment of Oral Biology, School of Dentistry, University of California, Los Angeles, CA 90095.ORCID 0000-0003-3253-0471
Xuesong HeDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142.
Anna EdlundGenomic Medicine Group, J. Craig Venter Institute, La Jolla, CA 92037.
Jeffrey S McLeanDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, WA 98195.ORCID 0000-0001-9934-5137
Wenyuan ShiDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142 wshi@forsyth.org.

Funding

Making a quantum leap in plaque research with modern sciencesR01DE020102 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, XUESONG, MCLEAN, JEFFREY SCOTT · 2010 to 2020
$3.7M
Studying the Protective Effects of Normal Oral FloraR01DE026186 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, XUESONG, MCLEAN, JEFFREY SCOTT · 2016 to 2020
$2.1M
Investigating Oral Pathogen Virulence within Complex Oral Biofilm CommunitiesR00DE024543 · NIDCR · J. CRAIG VENTER INSTITUTE, INC. · PI EDLUND, ANNA ELISABET · 2016 to 2018
$732k
Understanding S. Mutans Pathogenesis in a Social and Ecological SettingF32DE026947 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BAKER, JONATHON · 2017 to 2020
$186k
NIDCR NIH HHS R00 DE024543NIDCR NIH HHS R01 DE020102NIDCR NIH HHS R01 DE026186
6 · The paper itself

Abstract

It is well-understood that many bacteria have evolved to survive catastrophic events using a variety of mechanisms, which include expression of stress-response genes, quiescence, necrotrophy, and metabolic advantages obtained through mutation. However, the dynamics of individuals leveraging these abilities to gain a competitive advantage in an ecologically complex setting remain unstudied. In this study, we observed the saliva microbiome throughout the ecological perturbation of long-term starvation, allowing only the species best equipped to access and use the limited resources to survive. During the first several days, the community underwent a death phase that resulted in a ∼50-100-fold reduction in the number of viable cells. Interestingly, after this death phase, only three species,

Indexed as

Microbial ViabilityGastrointestinal MicrobiomeHumansKlebsiellaMouthProvidenciaSalivaKlebsiellamicrobial ecologyoral microbiome

Identifiers

PMID30975748
PMCPMC6486781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.