Evidence map›Paper›PMID 30975721›Full record

ArticleGenes & development2019

Structural basis for inhibition of a response regulator of σ

Victoria Dorich, Christiane Brugger, Arti Tripathi, Joel R Hoskins, Song Tong, Margaret M Suhanovsky, Amita Sastry, Sue Wickner, Susan Gottesman, Alexandra M Deaconescu

Abstract read
In one paragraph

Article in Genes & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Global analysis of protein degradation reveals instability of diverse regulators inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. RpoS and the bacterial general stress response.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  6. Structure of phosphorylated-like RssB, the adaptor delivering σThe Journal of biological chemistry · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Gain of SpontaneousFrontiers in bioengineering and biotechnology · 2021
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victoria DorichDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02903, USA.
Christiane Brugger *Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02903, USA.
Arti Tripathi *Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Joel R HoskinsLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Song TongLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Margaret M SuhanovskyDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02903, USA.
Amita SastryDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02903, USA.
Sue WicknerLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Susan GottesmanLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.ORCID 0000-0002-7792-1284
Alexandra M DeaconescuDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02903, USA.ORCID 0000-0002-2742-5493

Funding

Mechanisms for Stress-Induced Transcriptional Reprogramming via Anti-AdaptorsR01GM121975 · NIGMS · BROWN UNIVERSITY · PI DEACONESCU, ALEXANDRA M. · 2017 to 2021
$1.7M
NIGMS NIH HHS R01 GM121975
6 · The paper itself

Abstract

The stationary phase promoter specificity subunit σ

Indexed as

Bacterial ProteinsCrystallography, X-RayDNA-Binding ProteinsEscherichia coli ProteinsModels, MolecularProtein ConformationProtein Conformation, alpha-HelicalProtein DomainsProtein StabilitySigma FactorTranscription FactorsBacterial ProteinsDNA-Binding ProteinsEscherichia coli ProteinsIraD protein, E colirssB protein, E coliSigma Factorsigma factor KatF protein, BacteriaTranscription FactorsadaptorantiadaptorbacteriabiochemistryClpXPcrystallographystress response

Identifiers

PMID30975721
PMCPMC6546054

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.