Evidence map›Paper›PMID 30975700›Full record

ArticleDevelopment (Cambridge, England)2019

The fate of cells undergoing spontaneous DNA damage during development.

Agnes Miermont, Vlatka Antolović, Tchern Lenn, John M E Nichols, Lindsey J Millward, Jonathan R Chubb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Single Cell Transcriptome Analysis During Development in Dictyostelium.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Frontiers in cell and developmental biology · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Agnes MiermontMRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, London, UK.
Vlatka AntolovićMRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, London, UK.
Tchern LennMRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, London, UK.
John M E NicholsMRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, London, UK.ORCID 0000-0003-2061-1485
Lindsey J MillwardMRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, London, UK.
Jonathan R ChubbMRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, London, UK j.chubb@ucl.ac.uk.ORCID 0000-0001-6898-9765

Funding

Biotechnology and Biological Sciences Research Council BB/K017004/1Medical Research Council MC_U12266BWellcome Trust 202867/Z/16/Z
6 · The paper itself

Abstract

Embryonic development involves extensive and often rapid cell proliferation. An unavoidable side effect of cell proliferation is DNA damage. The consequences of spontaneous DNA damage during development are not clear. Here, we define an approach to determine the effects of DNA damage on cell fate choice. Using single cell transcriptomics, we identified a subpopulation of

Indexed as

DNA DamageGene Expression RegulationCell AdhesionCell LineageCell MovementCell Physiological PhenomenaDictyosteliumDNA RepairProtein BindingRad51 RecombinaseTranscriptomeRad51 RecombinaseCell-cell adhesionDictyosteliumDNA damageSingle cell transcriptomicsStochastic gene expression

Identifiers

PMID30975700
PMCPMC6602350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.