Observational studyAJNR. American journal of neuroradiology2019
Differences in Cerebral Aneurysm Rupture Rate According to Arterial Anatomies Depend on the Hemodynamic Environment.
Observational study in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Surgical treatment of giant intracranial aneurysms: A systematic review and single arm Meta-Analysis.Neurosurgical review · 2025Pooled it
- Computational Fluid Dynamics Approaches for Analyzing Rupture and Growth of Intracranial Aneurysms: A Systematic Review.Biomedicines · 2025Review
- Article
- Risk analysis of intracranial aneurysm rupture based on the arterial segment of origin.Frontiers in neurology · 2024Article
- Endothelial cells differentially sense laminar and disturbed flows by altering the lipid order of their plasma and mitochondrial membranes.American journal of physiology. Cell physiology · 2023Article
- Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis.Journal of personalized medicine · 2022Article
- Risk Factors for Recanalization after Coil Embolization.Journal of personalized medicine · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCerebral aneurysms have significantly different rupture rates depending on their size and location. The mechanisms underlying these differences are unclear. We examined whether anatomic rupture risks are dependent on the hemodynamic environment on the aneurysmal surface. MATERIALS AND
methodsPatient-specific geometries and flow rates of 84 cerebral aneurysms (42 anterior communicating artery and 42 MCA aneurysms) were acquired from our clinical study, the Computational Fluid Dynamics Analysis of Blood Flow in Cerebral Aneurysms: Prospective Observational Study. Pulsatile blood flow was simulated to calculate hemodynamic metrics with special attention to wall shear stress magnitude and temporal disturbance. Multivariate analyses were performed to identify associations between hemodynamic metrics and known rupture predictors (age, sex, hypertension, smoking history, location, and size).
resultsAll the wall shear stress magnitude-based metrics showed a significant negative association with size and location (
conclusionsThe differences in aneurysm rupture rates according to size and location may reflect differences in hemodynamic environments in qualitatively different ways. An enhanced multidirectional wall shear stress disturbance may be especially associated with aneurysm rupture.
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Registered trials
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