ArticleBrazilian journal of otorhinolaryngology
Evaluation of serum prolidase enzyme activity and oxidative stress in patients with tinnitus.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Trial
- Nrf2 deficiency enhances oxidative stress and promotes susceptibility to tinnitus in mice.Scientific reports · 2025Article
- Frailty links the heterogeneity of tinnitus disorder and response to interventions in older patients.Frontiers in neurology · 2025Review
- The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes.International journal of molecular sciences · 2023Review
- Migrainous Vertigo, Tinnitus, and Ear Symptoms and Alternatives.Otolaryngologic clinics of North America · 2022Review
- Objective and Measurable Biomarkers in Chronic Subjective Tinnitus.International journal of molecular sciences · 2021Review
- Causal relationship between genetically predicted Enzyme and Tinnitus risk: a two-sample bi-directional mendelian randomization study.Brazilian journal of otorhinolaryngologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTinnitus is defined as the perception of sound in the head or in the head in the absence of external sounds. The cause of tinnitus is still unknown.
objectiveWe aimed to compare the serum levels of total oxidant status, total antioxidant status, serum prolidase enzyme activity and the oxidative stress index in patients with tinnitus to those of normal subjects.
methodsTwenty five patients with tinnitus (mean age 34.3) and 25 healthy controls (mean age 37.2) were included in the study.
resultsTotal oxidant status levels in the patient group were significantly higher than in the control group (p=0.037). The mean total oxidant status value was 2.54±0.95mmoL/L in the patient group, and 2.06±0.98mmoL/L in the control group. The mean oxidative stress index level was 0.22±0.10AU in the patient group, while it was 0.17±0.08AU in the control group. Oxidative stress index was significantly higher in the patient group (0.026). There was no significant difference between the groups in terms of total antioxidant status values (p=0.838). The mean serum prolidase enzyme activity level was 202.74±33.56U/L in the patient group and 175.46±42.68U/L in the control group. Serum prolidase enzyme activity levels in the patient group were significantly higher than in the control group (0.040).
conclusionWe detected that the total oxidant status, oxidative stress index and serum prolidase enzyme activity levels were higher in patients with tinnitus when compared to the healthy controls. This finding suggests that oxidative stress index and serum prolidase enzyme activity may play a role in the etiopathogenesis of tinnitus.
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