ArticleDental materials : official publication of the Academy of Dental Materials2019
A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair.
Article in Dental materials : official publication of the Academy of Dental Materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Aptamer-Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Wnt/β-Catenin Pathway and Hydraulic Calcium Silicate-Based Cements: A Narrative Review.Dentistry journal · 2026Review
- Bioceramics Based on Li-Modified Bioactive Glasses for Bone Tissue Regeneration.Materials (Basel, Switzerland) · 2026Article
- Unraveling osteogenesis mechanisms of the empowered VitaFlux adaptive regeneration biomaterials for bone tissue engineering: Insights into the role of BBGs/BSBGs.Bioactive materials · 2025Review
- Fast Lithium-Releasing Phosphate Glasses Promote the Resolution of Inflammation.ACS applied bio materials · 2025Article
- Evaluation of the Structural, Biological, and Bone Induction Properties of Sol-Gel-Derived Lithium-Doped 68S Bioactive Glass-An in Vitro Study on Human Dental Pulp Stem Cells.Clinical and experimental dental research · 2025Article
- Bioactive Materials in Vital Pulp Therapy: Promoting Dental Pulp Repair Through Inflammation Modulation.Biomolecules · 2025Review
- Influence of Lithium- and Zinc-Containing Bioactive Glasses on Pulpal Regeneration.European journal of dentistry · 2023Article
- Multifunctional Lithium-Doped Mesoporous Nanoparticles for Effective Dentin Regeneration in vivo.International journal of nanomedicine · 2023Article
- Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine.Journal of functional biomaterials · 2022Review
- Lithium doped biphasic calcium phosphate: Structural analysis and osteo/odontogenic potentialFrontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesWnt/β-catenin signalling plays important roles in regeneration, particularly in hard tissues such as bone and teeth, and can be regulated by small molecule antagonists of glycogen synthase kinase 3 (GSK3); however, small molecules can be difficult to deliver clinically. Lithium (Li) is also a GSK3 antagonist and can be incorporated into bioactive glasses (BG), which can be used clinically in dental and bone repair applications and tuned to quickly release their constituent ions.
methodsHere, we created phosphate (P)- and borate (B)-based BG that also contained Li (LiPBG and LiBBG) and examined their ion release kinetics and the toxicity of their dissolution ions on mouse 17IA4 dental pulp cells.
resultsWe found that although LiPBG and LiBBG can both quickly release Li at concentrations known to regulate Wnt/β-catenin signalling, the P and B ions they concomitantly release are highly toxic to cells. Only when relatively low concentrations of LiPBG and LiBBG were placed in cell culture medium were their dissolution products non-toxic. However, at these concentrations, LiPBG and LiBBG's ability to regulate Wnt/β-catenin signalling was limited. SIGNIFICANCE: These data suggest that identifying a BG composition that can both quickly deliver high concentrations of Li and is non-toxic remains a challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.