Evidence map›Paper›PMID 30975470›Full record

ArticleBiochemical and biophysical research communications2019

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD

Claudia Chini, Kelly A Hogan, Gina M Warner, Mariana G Tarragó, Thais R Peclat, Tamar Tchkonia, James L Kirkland, Eduardo Chini

Open access · hybridAbstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 1 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. NADAging cell · 2026
    Article
  3. Article
  4. Review
  5. Nutrition Information Briefs - Niacin.Advances in nutrition (Bethesda, Md.) · 2026
    Article
  6. Skin Cancer Prevention and Antiaging: Role of Nicotinamide.International journal of molecular sciences · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Inhibition of CD38 by 78c Enhanced NADInternational journal of molecular sciences · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Protein Acetylation and NAD+ Homeostasis in Aging Muscle.Advances in experimental medicine and biology · 2025
    Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Claudia ChiniSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Ave. SW, Rochester, MN, 55905, USA.
Kelly A HoganSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Ave. SW, Rochester, MN, 55905, USA.
Gina M WarnerSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Ave. SW, Rochester, MN, 55905, USA.
Mariana G TarragóSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Ave. SW, Rochester, MN, 55905, USA.
Thais R PeclatSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Ave. SW, Rochester, MN, 55905, USA.
Tamar TchkoniaKogod Aging Center, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.
James L KirklandKogod Aging Center, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.
Eduardo ChiniSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Ave. SW, Rochester, MN, 55905, USA. Electronic address: chini.eduardo@mayo.edu.
Mayo Clinic · USWinnMed · US

Funding

The Sir2-p53-IGF Link in Mammalian Life-Span ControlR01AG026094 · NIA · UNIVERSITY OF VIRGINIA · PI CHINI, EDUARDO N · 2006 to 2016
$3.8M
Therapeutic implication of CD38 in CLLR01CA233790 · NCI · MAYO CLINIC JACKSONVILLE · PI CHINI, EDUARDO N · 2019 to 2023
$3.0M
Role of CD38 in NAD metabolism: from the basic biology of aging to translationR01AG058812 · NIA · MAYO CLINIC ROCHESTER · PI CHINI, EDUARDO N · 2018 to 2022
$2.0M
NCI NIH HHS R01 CA233790NIA NIH HHS R01 AG026094NIA NIH HHS R01 AG058812
6 · The paper itself

Abstract

Tissue nicotinamide adenine dinucleotide (NAD

Indexed as

Cellular SenescenceADP-ribosyl Cyclase 1AgingAnimalsCells, CulturedEndothelial CellsFemaleHumansHuman Umbilical Vein Endothelial CellsMacrophagesMice, Inbred C57BLMiddle AgedNADADP-ribosyl Cyclase 1NADAgingCD38InflammagingNAD(+)Senescence

Identifiers

PMID30975470
PMCPMC6486859
OpenAlexW2936767994

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.