Evidence map›Paper›PMID 30975217›Full record

ArticleTrials2019

Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial.

T Kiss, J Wittenstein, C Becker, K Birr, G Cinnella, E Cohen, M R El Tahan, L F Falcão, C Gregoretti, M Granell and 25 more

Erratum issued Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02963025 (PROtective Ventilation With High Versus Low PEEP During One-lung Ventilation for THORacic Surgery PROTHOR), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02963025 nacompletednot on this map

PROtective Ventilation With High Versus Low PEEP During One-lung Ventilation for THORacic Surgery PROTHOR: A Randomized Controlled Trial

TypeinterventionalSponsorTechnische Universität DresdenRan2017 to 2024Enrolled2,200ConditionsOne-Lung VentilationArmsPEEP level, Use of recruitment maneuvers
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 62 citations in OpenAlex.

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  19. Driving pressure guided ventilation.Korean journal of anesthesiology · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 16 countries.

T KissDepartment of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. thomas.kiss@uniklinikum-dresden.de.ORCID http://orcid.org/0000-0002-8276-1916
J WittensteinDepartment of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
C BeckerDepartment of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
K BirrDepartment of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
G CinnellaDepartment of Anesthesia and Intensive Care, OO Riuniti Hospital, University of Foggia, Foggia, Italy.
E CohenDepartment of Anesthesiology, The Mount Sinai Hospital, New York, USA.
M R El TahanImam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
L F FalcãoFederal University of São Paulo, Sao Paulo, Brazil.
C GregorettiUOC Anestesia e Rianimazione A.O.Universitaria "P. Giaccone", Dipartimento Di.Chir.On.S., Università degli Studi di Palermo, Palermo, Italy.
M GranellHospital General Universitario de Valencia, Valencia, Spain.
T HachenbergUniversity Hospital Magdeburg, Magdeburg, Germany.
M W HollmannDepartment of Anesthesiology, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
R JankovicClinic for Anesthesia and Intensive Therapy, Clinical Center Nis, School of Medicine, University of Nis, Nis, Serbia.
W KarzaiZentralklinik Bad Berka, Bad Berka, Germany.
J KrasslerThoracic Center Coswig, Coswig, Germany.
T LoopDepartment of Anesthesiology and Intensive Care Medicine Clinic, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
M J LickerUniversity Hospital Geneva, Geneva, Switzerland.
N MarczinSection of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
G H MillsDepartment of Anaesthesia and Intensive Care Medicine, Sheffield Teaching Hospitals, Sheffield University, Sheffield, UK.
M T MurrellDepartment of Anesthesiology, Weill Cornell Medicine, New York, USA.
V NeskovicMilitary Medical Academy, Belgrade, Serbia.
Z Nisnevitch-SavaresePenn State Hershey Anesthesiology & Perioperative Medicine, Hershey, USA.
P PelosiDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
R RossaintDepartment of Anaesthesiology, University Hospital Aachen, Aachen, Germany.
M J SchultzDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
A Serpa NetoDepartment of Critical Care, Hospital Israelita Albert Einstein, São Paulo, Brazil.
P SevergniniDipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Varese, Italy.
L SzegediDepartment of Anesthesiology, Centre Hospitalier Universitaire de Charleroi, Charleroi, Belgium.
T VeghDepartment of Anesthesiology and Intensive Care, University of Debrecen, Debrecen, Hungary.
G VoyagisDepartment of Anaesthesia, Postoperative ICU, Pain Relief & Palliative Care Clinic, "Sotiria" Chest Diseases Hospital, Athens, Greece.
J ZhongDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
M Gama de AbreuDepartment of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
M SenturkDepartment of Anaesthesiology and Intensive Care, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey.
PROTHOR investigators
Research Workgroup PROtective VEntilation Network (PROVEnet) of the European Society of Anaesthesiology (ESA)
University Hospital Carl Gustav Carus · DEHospital General Universitario De Valencia · ESMilitary Medical Academy · RSUniversity of Debrecen · HUUniversity of Foggia · ITUniversity of Freiburg · DEUniversity of Insubria · ITUniversity of Nis · RSAmsterdam UMC Location University of Amsterdam · NLCornell University · USImam Abdulrahman Bin Faisal University · SAIstanbul University · TRMahidol University · THMount Sinai Hospital · USPennsylvania State University · USRoyal Brompton & Harefield NHS Foundation Trust · GBSemmelweis University · HUShanghai Medical College of Fudan University · CNUniversidade Federal de São Paulo · BRUniversitätsklinikum Aachen · DE

Funding

Association of Anaesthetists of Great Britain and Ireland n/a
6 · The paper itself

Abstract

backgroundPostoperative pulmonary complications (PPC) may result in longer duration of in-hospital stay and even mortality. Both thoracic surgery and intraoperative mechanical ventilation settings add considerably to the risk of PPC. It is unclear if one-lung ventilation (OLV) for thoracic surgery with a strategy of intraoperative high positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) reduces PPC, compared to low PEEP without RM.

methodsPROTHOR is an international, multicenter, randomized, controlled, assessor-blinded, two-arm trial initiated by investigators of the PROtective VEntilation NETwork. In total, 2378 patients will be randomly assigned to one of two different intraoperative mechanical ventilation strategies. Investigators screen patients aged 18 years or older, scheduled for open thoracic or video-assisted thoracoscopic surgery under general anesthesia requiring OLV, with a maximal body mass index of 35 kg/m DISCUSSION: PROTHOR is the first randomized controlled trial in patients undergoing thoracic surgery with OLV that is adequately powered to compare the effects of intraoperative high PEEP with RM versus low PEEP without RM on PPC. The results of the PROTHOR trial will support anesthesiologists in their decision to set intraoperative PEEP during protective ventilation for OLV in thoracic surgery.

trial registrationThe trial was registered in clinicaltrials.gov ( NCT02963025 ) on 15 November 2016.

Indexed as

One-Lung VentilationPositive-Pressure RespirationThoracic Surgical ProceduresHumansIntraoperative ComplicationsMulticenter Studies as TopicRandomized Controlled Trials as TopicResearch DesignSample SizeMechanical ventilationone-lung ventilationpositive end-expiratory pressurepostoperative pulmonary complicationrecruitment maneuverthoracic surgery

Identifiers

PMID30975217
PMCPMC6460685
OpenAlexW2945860019

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.