Evidence map›Paper›PMID 30975196›Full record

Trial reportTrials2019

Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study.

Dhaneshwar Shep, Chitra Khanwelkar, Prakashchandra Gade, Satyanand Karad

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07238478 (Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of JDS-HF3.0 in Menopause Related Quality of Life Outcomes in Postmenopausal Women), which is not on this map. Cited by 65 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 10 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07238478 narecruitingnot on this mapstarted 2025, after this paper: background citation

Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of JDS-HF3.0 in Menopause Related Quality of Life Outcomes in Postmenopausal Women

TypeinterventionalSponsorBonafide HealthRan2025 to 2026Enrolled250ConditionsJoint Discomfort, Joint Pain, Stiffness, Function, Joint Pain, Hot FlashesArmsJDS-HF3.0, Placebo
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 10 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Pooled it
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  7. Efficacy and Safety of Curcumin andFrontiers in immunology · 2022
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  11. Trial
  12. Turmeric (Pharmaceutical biology · 2026
    Review
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dhaneshwar ShepKrishna Institute of Medical Sciences, Satara, Maharashtra, India. dhaneshshep@gmail.com.
Chitra KhanwelkarKrishna Institute of Medical Sciences, Satara, Maharashtra, India.
Prakashchandra GadeDr. Vithalrao Vikhe Patil Foundation's Medical College & Hospital, Ahmednagar, Maharashtra, India.
Satyanand KaradCity Care Accident Hospital, Parli Vaijnath, Beed, Maharashtra, India.
Krishna Institute of Medical Sciences · INDr. Vitthalrao Vikhe Patil Foundation’s Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study was to compare the efficacy and safety of curcumin with those of diclofenac in the treatment of knee osteoarthritis (OA).

methodsIn this randomized, open-label, parallel, active controlled clinical study, 139 patients with knee OA were randomly assigned to receive either a curcumin 500-mg (BCM-95

resultsAt days 14 and 28, patients receiving curcumin showed similar improvement in severity of pain and KOOS scale when compared with diclofenac, and the difference was not statistically significant. At day 7, the patients who received curcumin experienced a significantly greater reduction in the number of episodes of flatulence compared with diclofenac (P <0.01). At day 28, a weight-lowering effect (P <0.01) and anti-ulcer effect (P <0.01) of curcumin were observed. None of the patients required H2 blockers in the curcumin group, and 19 patients required H2 blockers in the diclofenac group (0% versus 28%, respectively; P <0.01). Adverse effects were significantly less in the curcumin group (13% versus 38% in the diclofenac group; P <0.01). Patient's and physician's global assessment of therapy was similar in the two treatment groups.

conclusionCurcumin has similar efficacy to diclofenac but demonstrated better tolerance among patients with knee OA. Curcumin can be an alternative treatment option in the patients with knee OA who are intolerant to the side effects of non-steroidal anti-inflammatory drugs.

trial registrationISRCTN, ISRCTN10074826 . Registered 21 November 2017 - Retrospectively registered.

Indexed as

AdultAgedAnti-Inflammatory Agents, Non-SteroidalCurcuminDiclofenacFemaleHumansMaleMiddle AgedOsteoarthritis, KneeResearch DesignAnti-Inflammatory Agents, Non-SteroidalCurcuminDiclofenacAnti-flatulentAnti-ulcerBCM-95CurcuminKnee osteoarthritisPainWeight-lowering

Identifiers

PMID30975196
PMCPMC6460672
OpenAlexW2936843542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.