SynthesisArthritis research & therapy2019
A simplified lung ultrasound for the diagnosis of interstitial lung disease in connective tissue disease: a meta-analysis.
Synthesis in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Early detection of RA‑ILD-A novel screening protocol with pulmonary function testing and lung ultrasound : A monocentric cohort study.Zeitschrift fur Rheumatologie · 2026Article
- Thoracic Ultrasound in Assessment of the Pleura in Connective Tissue Disease.Archives of rheumatology · 2025Article
- Comparison of quantitative lung ultrasound scores with automated quantitative CT: to overcome the ultrasound limitations.Rheumatology (Oxford, England) · 2025Article
- The diagnostic utility of lung ultrasound in the assessment of interstitial lung disease associated with rheumatoid arthritis.Arthritis research & therapy · 2025Article
- A Proposal for a New Lung Ultrasound Score in Rheumatoid Arthritis: The Reliability of Lung Ultrasound for Rheumatoid Arthritis-Associated Interstitial Lung Disease Diagnosis.Journal of clinical medicine · 2025Article
- Thoracic ultrasound in interstitial lung disease.Breathe (Sheffield, England) · 2025Article
- Ultrasound Beyond Joints: A Review of Extra-Articular Applications in Rheumatology.Current rheumatology reports · 2025Review
- Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD): Update on Prevalence, Risk Factors, Pathogenesis, and Therapy.Current rheumatology reports · 2024Review
- Practical Use of Ultrasound in Modern Rheumatology-From A to Z.Life (Basel, Switzerland) · 2024Review
- High Prevalence of the Lung Ultrasound Interstitial Syndrome in Systemic Sclerosis Patients with Normal HRCT and Lung Function-A Pilot Study.Journal of clinical medicine · 2024Article
- Usefulness of Lung Ultrasound as a Method for Early Diagnosis of Interstitial Lung Disease in Patients with Rheumatoid Arthritis.Open access rheumatology : research and reviews · 2024Article
- Automated Lung Ultrasound Pulmonary Disease Quantification Using an Unsupervised Machine Learning Technique for COVID-19.Diagnostics (Basel, Switzerland) · 2023Article
- Pulmonary Ultrasonography in Systemic Sclerosis-Induced Interstitial Lung Disease-A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- Unmet needs and perspectives in rheumatoid arthritis-associated interstitial lung disease: A critical review.Frontiers in medicine · 2023Review
- Article
- Evaluation of connective tissue disease-related interstitial lung disease using ultrasound elastography: a preliminary study.Quantitative imaging in medicine and surgery · 2022Article
- High-Resolution Computed Tomography and Lung Ultrasound in Patients with Systemic Sclerosis: Which One to Choose?Diagnostics (Basel, Switzerland) · 2021Review
- Lung Ultrasound in the Screening of Pulmonary Interstitial Involvement Secondary to Systemic Connective Tissue Disease: A Prospective Pilot Study Involving 180 Patients.Journal of clinical medicine · 2021Article
- Use of ultrasound to diagnose and monitor interstitial lung disease in rheumatic diseases.Clinical rheumatology · 2021Review
- The role of lung ultrasound B-lines and serum KL-6 in the screening and follow-up of rheumatoid arthritis patients for an identification of interstitial lung disease: review of the literature, proposal for a preliminary algorithm, and clinical application to cases.Arthritis research & therapy · 2021Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInterstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with different lung intercostal spaces (LIS). The purpose of this meta-analysis was to find a simplified LUS method for the assessment of CTD-ILD.
methodsWe systematically retrieved lung ultrasound diagnostic studies on CTD-ILD in PubMed, Embase, and Web of Science databases. Summary diagnostic accuracy, including sensitivity, specificity, and area under the curve (AUC), was analyzed. Subgroup analysis was conducted according to different LIS and diseases.
resultsThe 11 studies included in this meta-analysis comprised a total of 487 patients with CTD. The pooled sensitivity and specificity of the LUS were 0.859 (95% confidence interval (CI) 0.812-0.898) and 0.839 (95% CI 0.782-0.886), respectively, illustrating its great value for CTD-ILD diagnosis. In addition, there were six methods to evaluate LIS, including 72, 65, 50, 14, 10, and all LIS. The pooled sensitivity and specificity of 14 LIS were 0.982 (95% CI 0.904-1.000) and 0.875 (95% CI 0.710-0.965), respectively. The pooled positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odd ratio (DOR) of 14 LIS were 7.297 (95% CI 6.050-17.45), 0.029 (95% CI 0.006-0.147), and 292.30 (95% CI 35.53-2403.8), respectively. Moreover, the AUC for systemic sclerosis (SSc) and rheumatoid arthritis (RA) was 0.929 and 0.981, respectively; the DOR for SSc and RA was 42.93 (95% CI 17.75-103.79) and 80.24 (95% CI 8.107-796.09), respectively.
conclusionsWe found a modified and simplified method of LUS, by scanning 14 LIS in a short time, which had a very high sensitivity and specificity.
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Registered trials
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