Evidence map›Paper›PMID 30975125›Full record

ArticleBMC cancer2019

Functional role of SGK3 in PI3K/Pten driven liver tumor development.

Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M Pascale and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Hui CaoDepartment of Oncology, Guizhou Provincial People's Hospital, Medical College of Guizhou University, Guiyang, People's Republic of China.
Zhong XuDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, UCSF, 513 Parnassus Ave, San Francisco, CA, 94143, USA.
Jingxiao WangDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, UCSF, 513 Parnassus Ave, San Francisco, CA, 94143, USA.
Antonio CiglianoNational Institute of Gastroenterology "S. de Bellis", Research Hospital, Castellana Grotte, Italy.
Maria G PiloDepartment of Clinical and Experimental Medicine, University of Sassari, via P. Manzella 4, 07100, Sassari, Italy.
Silvia RibbackInstitute of Pathology, University of Greifswald, Greifswald, Germany.
Shu ZhangDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, UCSF, 513 Parnassus Ave, San Francisco, CA, 94143, USA.
Yu QiaoDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, UCSF, 513 Parnassus Ave, San Francisco, CA, 94143, USA.
Li CheDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, UCSF, 513 Parnassus Ave, San Francisco, CA, 94143, USA.
Rosa M PascaleDepartment of Clinical and Experimental Medicine, University of Sassari, via P. Manzella 4, 07100, Sassari, Italy.
Diego F CalvisiDepartment of Clinical and Experimental Medicine, University of Sassari, via P. Manzella 4, 07100, Sassari, Italy. calvisid@uniss.it.
Xin ChenDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, UCSF, 513 Parnassus Ave, San Francisco, CA, 94143, USA. chenx@pharmacy.ucsf.edu.
University of California, San Francisco · USUniversity of Sassari · ITBeijing Hospital · CNGastroenterology Hospital "Saverio de Bellis" · ITGuizhou Provincial People's Hospital · CNUniversität Greifswald · DE

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Molecular Genetics of Liver CancersR01CA136606 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, XIN · 2009 to 2016
$2.6M
Guizhou Provincial Department of Science and Technology 2012-2241Liver Center, University of California, San Francisco P30DK026743National Natural Science Foundation of China 31360220NCI NIH HHS R01 CA136606NCI NIH HHS R01CA136606NIDDK NIH HHS P30 DK026743the Italian Association Against Cancer IG 12139
6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of PI3K catalytic subunit alpha (PIK3CA) and/or loss of Pten often occur in human HCCs. Serum and glucocorticoid kinase 3 (SGK3) belongs to the SGK family of AGK kinases and functions in parallel to AKT downstream of PI3K. Previous studies have shown that SGK3 may be the major kinase responsible for the oncogenic potential of PIK3CA helical domain mutants, such as PIK3CA(E545K), but not kinase domain mutants, such as PIK3CA(H1047R).

methodsWe investigated the functional contribution of SGK3 in mediating activated PIK3CA mutant or loss of Pten induced HCC development using Sgk3 knockout mice.

resultsWe found that ablation of Sgk3 does not affect PIK3CA(H1047R) or PIK3CA(E545K) induced lipogenesis in the liver. Using PIK3CA(H1047R)/c-Met, PIK3CA(E545K)/c-Met, and sgPten/c-Met murine HCC models, we also demonstrated that deletion of Sgk3 moderately delays PIK3CA(E545K)/c-Met driven HCC, while not affecting PIK3CA(H1047R)/c-Met or sgPten/c-Met HCC formation in mice. Similarly, in human HCC cell lines, silencing of SGK3 reduced PIK3CA(E545K) -but not PIK3CA(H1047R)- induced accelerated tumor cell proliferation.

conclusionAltogether, our data suggest that SGK3 plays a role in transducing helical domain mutant PIK3CA signaling during liver tumor development.

Indexed as

AgedAnimalsCarcinoma, HepatocellularCell Line, TumorCell ProliferationClass I Phosphatidylinositol 3-KinasesDisease Models, AnimalFemaleHumansLiverLiver NeoplasmsMaleMiceMice, KnockoutMiddle AgedProtein DomainsClass I Phosphatidylinositol 3-KinasesPIK3CA protein, humanProtein Serine-Threonine KinasesPTEN PhosphohydrolasePTEN protein, humanRNA, Small InterferingSerum-Glucocorticoid Regulated KinasesSGK3 protein, humanSgk3 protein, mousec-MetLiver cancermTORPIK3CA mutantsPtenSGK3

Identifiers

PMID30975125
PMCPMC6458829
OpenAlexW2944904034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.