ReviewViruses2019
Hypopituitarism after Orthohantavirus Infection: What is Currently Known?
Review in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Cross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infection.EBioMedicine · 2026Article
- Hemorrhagic fever with renal syndrome complicated by reversible secondary hyperparathyroidism during renal recovery: a case report.Frontiers in medicine · 2026Article
- Relationship between COVID-19 and hypopituitarism: A two-sample Mendelian randomization study.IBRO neuroscience reports · 2025Article
- An overview of hypopituitarism's causes.Frontiers in endocrinology · 2025Review
- Hypopituitarism and COVID-19.Pituitary · 2024Review
- Partial hypopituitarism with ACTH deficiency as the main manifestation as a complication of hemorrhagic fever with renal syndrome.BMC endocrine disorders · 2024Article
- Safety of emergency endoscopic endonasal surgery in COVID-positive patients with hemorrhagic complications of pituitary region tumors: A case report and review of the literature.Surgical neurology international · 2024Article
- Viruses and Endocrine Diseases.Microorganisms · 2023Review
- COVID-19 and hypopituitarism.Reviews in endocrine & metabolic disorders · 2022Review
- Long-Term Consequences of Puumala Hantavirus Infection.Viruses · 2022Article
- Coronavirus Disease 2019 and Pituitary Apoplexy: A Single-Center Case Series and Review of the Literature.World neurosurgery · 2021Review
- COVID-19 and the pituitary.Pituitary · 2021Review
- Review
- A Rare Case of SARS-CoV-2 Infection Associated With Pituitary Apoplexy Without Comorbidities.Journal of the Endocrine Society · 2021Article
- Coronavirus disease 2019 infection and pituitary apoplexy: A causal relation or just a coincidence? A case report and review of the literature.Surgical neurology international · 2021Article
- Orthohantavirus Pathogenesis and Cell Tropism.Frontiers in cellular and infection microbiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several case reports have described hypopituitarism following orthohantavirus infection, mostly following Puumala virus. The pathogenesis of this seemingly rare complication of orthohantavirus infection remains unknown. This review explores the possible pathophysiological mechanisms of pituitary damage due to orthohantavirus infection. In only three out of the 28 reported cases, hypopituitarism was detected during active infection. In the remaining cases, detection of pituitary damage was delayed, varying from two months up to thirteen months post-infection. In these cases, hypopituitarism remained undetected during the acute phase of infection or only occurred weeks to months post infection. Both ischemic and hemorrhagic damage of the pituitary gland have been detected in radiographic imaging and post-mortem studies in the studied case reports series. Ischemic damage could be caused by hypotension and/or vasospasms during the acute phase of hemorrhagic fever with renal syndrome (HFRS) while hemorrhage could be caused by thrombocytopenia, thrombopathy, and other known causes of coagulation disorders during orthohantavirus infection. Also, hypophysitis due to the presence of auto-antibodies have been suggested in the literature. In conclusion, a significant number of case reports and series describe hypopituitarism after orthohantavirus infection. In most cases hypopituitarism was diagnosed with a delay and therefore could very well be underreported. Clinicians should be aware of this potential endocrine complication, with substantial morbidity, and if unrecognized, significant mortality.
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Registered trials
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