ArticleNeuroImage2019
Neural correlates of inhibition and reward are negatively associated.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The resting-state brain activity signatures for addictive disorders.Med (New York, N.Y.) · 2024Pooled it
- Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration.Drug and alcohol dependence · 2020Trial
- Neural Correlates of Inhibitory Control in Impulsivity Traits in Non-Ecological Human-Computer Tasks: An ALE Meta-Analysis.Brain sciences · 2026Review
- Neural imbalance between feedback sensitivity and motor inhibition in compulsivity and negative urgency.Translational psychiatry · 2026Article
- The effect of stress on delay discounting in female patients with early-onset bulimia nervosa and alcohol use disorder: functional magnetic resonance imaging study.BJPsych open · 2025Article
- A pilot study of impulsivity and subjective alcohol response in the lab and moment.Experimental and clinical psychopharmacology · 2025Article
- The moderating role of trait impulsivity on reward sensitivity and alcohol craving.Addictive behaviors · 2025Article
- Reward and Inhibitory Control as Mechanisms and Treatment Targets for Binge Eating Disorder.Current psychiatry reports · 2024Review
- Transcranial Direct Current Stimulation Decreases P3 Amplitude and Inherent Delta Activity during a Waiting Impulsivity Paradigm: Crossover Study.Brain sciences · 2024Article
- Static and dynamic changes of intrinsic brain local connectivity in internet gaming disorder.BMC psychiatry · 2023Article
- Binge-Eating Precursors in Children and Adolescents: Neurodevelopment, and the Potential Contribution of Ultra-Processed Foods.Nutrients · 2023Review
- Neurodevelopmental Model Explaining Associations between Sex Hormones, Personality, and Eating Pathology.Brain sciences · 2023Review
- Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial.Frontiers in psychiatry · 2023Article
- Distinct Roles of the Human Subthalamic Nucleus and Dorsal Pallidum in Parkinson's Disease Impulsivity.Biological psychiatry · 2022Article
- A Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity.Frontiers in behavioral neuroscience · 2022Review
- Functional dynamics of dopamine synthesis during monetary reward and punishment processing.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Like me Back: Neural Correlates of Low Perceived Relational Value in Peer Victimized Youth.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2021Article
- Trajectories of brain development reveal times of risk and factors promoting resilience to alcohol use during adolescence.International review of neurobiology · 2021Review
- Inhibitory neuromodulation of the putamen to the prefrontal cortex in Internet gaming disorder: How addiction impairs executive control.Journal of behavioral addictions · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Individuals with impulsive and addictive disorders, including drug addiction, binge eating/obesity, and problem gambling, exhibit both impaired control over behavior and heightened sensitivity to reward. However, it is not known whether such deviation in inhibitory and reward circuitry among clinical populations is a cause or consequence of the disorders. Recent evidence suggests that these constructs may be related at the neural level, and together, increase risk for engaging in maladaptive behaviors. The current study examined the degree to which brain function during inhibition relates to brain function during receipt of reward in healthy young adults who have not yet developed problem behaviors. Participants completed the stop signal task to assess inhibitory control and the doors task to assess reactivity to monetary reward (win vs loss) during functional magnetic resonance imaging (fMRI). Brain activation during response inhibition was negatively correlated with brain activation during reward. Specifically, less brain activation in right prefrontal regions during inhibition, including the right inferior frontal gyrus, middle frontal gyrus, and supplementary motor area, was associated with greater brain activation in left ventral striatum during receipt of monetary reward. Moreover, these associations were stronger in binge drinkers compared to non-binge drinkers. These findings suggest that the systems are related even before the onset of impulsive or addictive disorders. As such, it is possible that the association between inhibitory and reward circuitry may be a prospective marker of risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.