ReviewNeurogastroenterology and motility2019
Ineffective esophageal motility: Concepts, future directions, and conclusions from the Stanford 2018 symposium.
Review in Neurogastroenterology and motility, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.
- Esophageal and Oropharyngeal Dysphagia: Clinical Recommendations From the United European Gastroenterology and European Society for Neurogastroenterology and Motility.United European gastroenterology journal · 2025Guideline
- Ineffective Esophageal Motility and Its Predictors in Gastroesophageal Reflux Disease Patients with Pathologic Acid Exposure Time.Journal of neurogastroenterology and motility · 2026Article
- Multidisciplinary Assessment and Management of Functional Dysphagia.Gastro hep advances · 2026Review
- Pathophysiology of Gastroesophageal Reflux Disease.Digestion · 2026Review
- Esophageal motility disorders after COVID-19 infection.Scientific reports · 2025Observational
- Unlocking the secrets of esophageal motility: how ineffective motility influences dysphagia and LES function following robotic hiatal hernia repair.Surgical endoscopy · 2025Article
- Long-term Prognosis and Prognostic Factors in Ineffective Esophageal Motility.Journal of neurogastroenterology and motility · 2025Article
- Clinical characteristics and esophageal motility in patients with gastric cardia submucosal tumors and associated changes after endoscopic resection.Surgical endoscopy · 2025Article
- Review
- Optimizing Assessment of Contraction Reserve in Ineffective Esophageal Motility: A Study of Upright Multiple Rapid Swallows.Journal of neurogastroenterology and motility · 2025Article
- The role of high-resolution manometry in a resource challenged service.Journal of the colleges of medicine of South Africa · 2025Article
- The Clinical Spectrum of Gastroesophageal Reflux Disease: Facts and Fictions.Visceral medicine · 2024Review
- Novel Technique to Diagnose Gastroesophageal Reflux Disease.The Korean journal of helicobacter and upper gastrointestinal research · 2024Review
- A practical approach to ineffective esophageal motility.Neurogastroenterology and motility · 2024Review
- Impact of Esophageal Motility on Microbiome Alterations in Symptomatic Gastroesophageal Reflux Disease Patients With Negative Endoscopy: Exploring the Role of Ineffective Esophageal Motility and Contraction Reserve.Journal of neurogastroenterology and motility · 2024Article
- Utilizing Esophageal Motility Tests in Diagnosing and Evaluating Gastroesophageal Reflux Disease.Diagnostics (Basel, Switzerland) · 2024Review
- Multicentric short term and safety study of ineffective esophageal motility patients treated with RefluxStop device.Scientific reports · 2024Observational
- The Milan score: A novel manometric tool for a more efficient diagnosis of gastro-esophageal reflux disease.United European gastroenterology journal · 2024Article
- Esophageal Infusion of Menthol Does Not Affect Esophageal Motility in Patients with Gastroesophageal Reflux Disease.Dysphagia · 2024Article
- Short-term results of laparoscopic anti-reflux surgery with the RefluxStop device in patients with gastro-esophageal reflux disease and ineffective esophageal motility.Langenbeck's archives of surgery · 2024Article
Corrections and comments
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Authors and funding
13 authors at 10 institutions in 5 countries.
Funding
Abstract
backgroundIneffective esophageal motility (IEM) is a heterogenous minor motility disorder diagnosed when ≥50% ineffective peristaltic sequences (distal contractile integral <450 mm Hg cm s) coexist with normal lower esophageal sphincter relaxation (integrated relaxation pressure < upper limit of normal) on esophageal high-resolution manometry (HRM). Ineffective esophageal motility is not consistently related to disease states or symptoms and may be seen in asymptomatic healthy individuals. PURPOSE: A 1-day symposium of esophageal experts reviewed existing literature on IEM, and this review represents the conclusions from the symposium. Severe IEM (>70% ineffective sequences) is associated with higher esophageal reflux burden, particularly while supine, but milder variants do not progress over time or consistently impact quality of life. Ineffective esophageal motility can be further characterized using provocative maneuvers during HRM, especially multiple rapid swallows, where augmentation of smooth muscle contraction defines contraction reserve. The presence of contraction reserve may predict better prognosis, lesser reflux burden and confidence in a standard fundoplication for surgical management of reflux. Other provocative maneuvers (solid swallows, standardized test meal, rapid drink challenge) are useful to characterize bolus transit in IEM. No effective pharmacotherapy exists, and current managements target symptoms and concurrent reflux. Novel testing modalities (baseline and mucosal impedance, functional lumen imaging probe) show promise in elucidating pathophysiology and stratifying IEM phenotypes. Specific prokinetic agents targeting esophageal smooth muscle need to be developed for precision management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.