Evidence map›Paper›PMID 30973928›Full record

ArticlePloS one2019

Neutrophil count as the centerpiece in the joined association networks of inflammatory and cell damage markers, and neuroendocrine stress markers in patients with stable angina pectoris following stenting.

Tamás Horváth, Gyöngyi Serfőző, Ádám Györkei, Imre Földesi, Tamás Forster, Margit Keresztes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tamás HorváthInvasive Cardiology Unit, Centre of Cardiology, Medical Faculty, University of Szeged, Szeged, Hungary.
Gyöngyi SerfőzőDepartment of Biochemistry, Medical Faculty, University of Szeged, Szeged, Hungary.
Ádám GyörkeiSynthetic and Systems Biology Unit, Biological Research Centre, Szeged, Hungary.
Imre FöldesiDepartment of Laboratory Medicine, Medical Faculty, University of Szeged, Szeged, Hungary.
Tamás ForsterCentre of Cardiology, Medical Faculty, University of Szeged, Szeged, Hungary.
Margit KeresztesDepartment of Biochemistry, Medical Faculty, University of Szeged, Szeged, Hungary.ORCID 0000-0001-5208-9682
University of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe primary aim of this study was to examine whether markers of cell damage and of the psycho-neuroendocrino-inflammatory/immune (PNI) system could be associated in patients with stable coronary artery disease (CAD) on the next day following percutaneous coronary intervention (PCI). MATERIALS AND

methodsBlood samples of 23 patients (18 men and five women, mean age 62.9 ± 10.6 years), were collected immediately before (pre-PCI), immediately after (post-PCI), and on the day following PCI (1d-PCI). Lactoferrin, LL-37 and interleukin-6 (IL-6) were assayed in plasma, in addition to cortisol and chromogranin A (CgA), as well as CK, ASAT and ALAT. Total and differential leukocyte counts were also analysed.

resultsAt all the three time points, the monocyte fractions, the monocyte-to-lymphocyte and the neutrophil-to-lymphocyte ratios and CgA levels were elevated. We detected significant peri-procedural changes in the plasma levels of our PNI markers: IL-6 (p<0.05), lactoferrin, LL-37 (both: p <0.0001), CgA, (p<0.05), and cortisol (p<0.01). On the first day after PCI, highly significant associations were found of ASAT with IL-6 and neutrophil count (both: r>0.75, p<0.0001), and of CgA with neutrophil count and monocyte count (both: r>0.79, p<0.0001); furthermore, cortisol was also associated with neutrophil count (r>0.7, p<0.0001).

conclusionsThe findings suggest that myocardial damage could correlate not only with an inflammatory reaction but, via neutrophil count, also with increased level of stress in stable CAD after PCI. Furthermore, 1d-PCI neutrophil count may serve as an easy-to-obtain integrative PNI measure in stable CAD.

Indexed as

NeutrophilsAdultAgedAlanine TransaminaseAngina, StableAntimicrobial Cationic PeptidesAspartate AminotransferasesBiomarkersCathelicidinsChromogranin ACreatine KinaseFemaleHumansHydrocortisoneInterleukin-6LactoferrinAlanine TransaminaseAntimicrobial Cationic PeptidesAspartate AminotransferasesBiomarkersCathelicidinsCHGA protein, humanChromogranin ACreatine KinaseHydrocortisoneIL6 protein, humanInterleukin-6LactoferrinLTF protein, human

Identifiers

PMID30973928
PMCPMC6459524
OpenAlexW2936477185

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.