ReviewPLoS computational biology2019
Network motifs and their origins.
Review in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Format-Preserving Reduction of Canonical Nonlinear Models.Bulletin of mathematical biology · 2026Article
- How synchronized human networks escape local minima.Nature communications · 2024Article
- Compression-based inference of network motif sets.PLoS computational biology · 2024Article
- Human and animal dominance hierarchies show a pyramidal structure guiding adult and infant social inferences.Nature human behaviour · 2023Article
- Rapid monitoring of ecological persistence.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Local and collective transitions in sparsely-interacting ecological communities.PLoS computational biology · 2022Article
- Network Theoretical Approach to Explore Factors Affecting Signal Propagation and Stability in Dementia's Protein-Protein Interaction Network.Biomolecules · 2022Article
- Aging at Evolutionary Crossroads: Longitudinal Gene Co-expression Network Analyses of Proximal and Ultimate Causes of Aging in Bats.Molecular biology and evolution · 2022Article
- The gene regulatory network ofFrontiers in microbiology · 2022Article
- Mechanotransduction as a major driver of cell behaviour: mechanisms, and relevance to cell organization and future research.Open biology · 2021Review
- Divide-and-conquer: machine-learning integrates mammalian and viral traits with network features to predict virus-mammal associations.Nature communications · 2021Article
- Short loop functional commonality identified in leukaemia proteome highlights crucial protein sub-networks.NAR genomics and bioinformatics · 2021Article
- Percolation of heterogeneous flows uncovers the bottlenecks of infrastructure networks.Nature communications · 2021Article
- Patterns of ties in problem-solving networks and their dynamic properties.Scientific reports · 2020Article
- A compiler for biological networks on silicon chips.PLoS computational biology · 2020Article
- Evolving complexity: how tinkering shapes cells, software and ecological networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- A Guide to Conquer the Biological Network Era Using Graph Theory.Frontiers in bioengineering and biotechnology · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern network science is a new and exciting research field that has transformed the study of complex systems over the last 2 decades. Of particular interest is the identification of small "network motifs" that might be embedded in a larger network and that indicate the presence of evolutionary design principles or have an overly influential role on system-wide dynamics. Motifs are patterns of interconnections, or subgraphs, that appear in an observed network significantly more often than in compatible randomized networks. The concept of network motifs was introduced into Systems Biology by Milo, Alon and colleagues in 2002, quickly revolutionized the field, and it has had a huge impact in wider scientific domains ever since. Here, we argue that the same concept and tools for the detection of motifs were well known in the ecological literature decades into the last century, a fact that is generally not recognized. We review the early history of network motifs, their evolution in the mathematics literature, and their recent rediscoveries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.