Evidence map›Paper›PMID 30973800›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020

Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by

Valeria T Barletta, Elena Herranz, Costantina A Treaba, Russell Ouellette, Ambica Mehndiratta, Marco L Loggia, Eric C Klawiter, Carolina Ionete, Sloane A Jacob, Caterina Mainero

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Advanced MRI quantification of neuroinflammatory disorders.Journal of neuroscience research · 2022
    Article
  9. Cytokine Signalling at the Microglial Penta-Partite Synapse.International journal of molecular sciences · 2021
    Review
  10. Review
  11. The Neuroimmunology of Chronic Pain: From Rodents to Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Valeria T BarlettaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0655-9406
Elena HerranzAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA.
Costantina A TreabaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA.
Russell OuelletteAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA/Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ambica MehndirattaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
Marco L LoggiaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA.
Eric C KlawiterDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA.
Carolina IoneteMultiple Sclerosis Center, UMass Memorial Medical Center, Worcester, MA, USA.
Sloane A JacobDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA/Harvard Medical School, Boston, MA, USA.
Caterina MaineroAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA.
Harvard University · USBeth Israel Deaconess Medical Center · USKarolinska Institutet · SEMassachusetts General Hospital · USUMass Memorial Health Care · US

Funding

Cortical mechanisms of disease progression in early multiple sclerosisR01NS078322 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MAINERO, CATERINA · 2013 to 2017
$1.9M
NINDS NIH HHS R01 NS078322
6 · The paper itself

Abstract

backgroundActivated microglia, which can be detected in vivo by

objectivesWe aimed at characterizing cerebellar neuroinflammation in MS patients compared to healthy subjects by combining

methodsTwenty-eight MS patients and 16 healthy controls underwent

resultsIn all cerebellar regions examined, MS patients showed abnormally increased tracer uptake, which correlated with cognitive and neurological disability.

conclusionNeuroinflammation is widespread in the cerebellum of patients with MS and related to neurological disability and cognitive impairment.

Indexed as

CerebellumInflammationMicrogliaMultiple SclerosisNeuroimagingWhite MatterAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultimodal ImagingPositron-Emission TomographyPyrimidines(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinaminePyrimidinesCerebellummicrogliaMR-PETneuroinflammation

Identifiers

PMID30973800
PMCPMC6788961
OpenAlexW2938195059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.