Evidence map›Paper›PMID 30973703›Full record

ArticleBioconjugate chemistry2019

Noninvasive Imaging and Quantification of Radiotherapy-Induced PD-L1 Upregulation with

Emily B Ehlerding, Hye Jin Lee, Todd E Barnhart, Dawei Jiang, Lei Kang, Douglas G McNeel, Jonathan W Engle, Weibo Cai

Open access · greenAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  7. Noninvasive PET imaging of tumor PD-L1 expression withAmerican journal of nuclear medicine and molecular imaging · 2024
    Article
  8. Research square · 2023
    Article
  9. Article
  10. Review
  11. ImmunoPET Imaging with 89Zr-Labeled Atezolizumab Enables In Vivo Evaluation of PD-L1 in Tumorgraft Models of Renal Cell Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  12. Radioimmunotherapy study ofEJNMMI research · 2022
    Article
  13. Review
  14. Development of Radiotracers for Imaging of the PD-1/PD-L1 Axis.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  15. Article
  16. Review
  17. Preclinical antibody-PET imaging of PD-L1.Frontiers in nuclear medicine · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Emily B EhlerdingMedical Physics Department , University of Wisconsin-Madison , 1111 Highland Avenue , Madison , Wisconsin 53705 , United States.
Hye Jin LeePharmaceutical Sciences Department , University of Wisconsin-Madison , 777 Highland Avenue , Madison , Wisconsin 53705 , United States.
Todd E BarnhartMedical Physics Department , University of Wisconsin-Madison , 1111 Highland Avenue , Madison , Wisconsin 53705 , United States.
Lei Kang
Douglas G McNeelDepartment of Medicine , University of Wisconsin-Madison , 1685 Highland Avenue , Madison , Wisconsin 53705 , United States.
Jonathan W EngleMedical Physics Department , University of Wisconsin-Madison , 1111 Highland Avenue , Madison , Wisconsin 53705 , United States.
Weibo CaiMedical Physics Department , University of Wisconsin-Madison , 1111 Highland Avenue , Madison , Wisconsin 53705 , United States.ORCID 0000-0003-4641-0833
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
NCI NIH HHS P30 CA014520NCI NIH HHS T32 CA009206NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

Immune checkpoint expression is highly dynamic, and combination treatments including radiotherapy can particularly modulate this expression. PET imaging using

Indexed as

Up-RegulationAntibodies, Monoclonal, HumanizedB7-H1 AntigenCell Line, TumorHumansLung NeoplasmsRadiopharmaceuticalsZirconiumAntibodies, Monoclonal, HumanizedatezolizumabB7-H1 AntigenCD274 protein, humanRadiopharmaceuticalsZirconium

Identifiers

PMID30973703
PMCPMC6521689
OpenAlexW2938932250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.