Observational studyJAMA otolaryngology-- head & neck surgery2019
Association of Positive Airway Pressure Prescription With Mortality in Patients With Obesity and Severe Obstructive Sleep Apnea: The Sleep Heart Health Study.
Observational study in JAMA otolaryngology-- head & neck surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Positive airway pressure therapy and all-cause and cardiovascular mortality in people with obstructive sleep apnoea: a systematic review and meta-analysis of randomised controlled trials and confounder-adjusted, non-randomised controlled studies.The Lancet. Respiratory medicine · 2025Pooled it
- Long-term effects on clinical event, mental health, and related outcomes of CPAP for obstructive sleep apnea: a systematic review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Pooled it
- Large variability in definitions of sleep apnea indices used in clinical studies.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Pooled it
- Who Really Benefits from CPAP? Disease Severity, Response Quality, and Long-Term Survival in Obstructive Sleep Apnea.Advances in respiratory medicine · 2026Article
- Predictor of Mortality in Obstructive Sleep Apnea: Results of Explainable Deep Learning-Based Survival Analysis from a 15-Year Follow-Up.Respiration; international review of thoracic diseases · 2026Article
- Obstructive Sleep Apnea and Arrhythmia: A Narrative Review of Arrhythmogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2026Review
- Exploratory Analysis of Liraglutide Effects on Obstructive Sleep Apnea and Health-Related Quality of Life in Individuals With Obesity and COPD: A Secondary Analysis of a Randomised Controlled Trial.Clinical obesity · 2026Observational
- The neutrophil-to-lymphocyte ratio is associated with increased risk of all-cause mortality in obstructive sleep apnea.Scientific reports · 2025Article
- Objective Sleep Duration and All-Cause Mortality Among People With Obstructive Sleep Apnea.JAMA network open · 2023Article
- Impact of CPAP Therapy Adherence on Global Cognition in Patients with Moderate to Severe Obstructive Sleep Apnea: A One-Year Follow-Up.Medicina (Kaunas, Lithuania) · 2023Article
- Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells.Scientific reports · 2022Article
- Cardiovascular Complications of Obstructive Sleep Apnea in the Intensive Care Unit and Beyond.Medicina (Kaunas, Lithuania) · 2022Review
- Positive airway pressure for the treatment of the childhood obstructive sleep apnea syndrome.Pediatric pulmonology · 2022Review
- Association between obstructive sleep apnea and cardiovascular diseases.Acta biochimica et biophysica Sinica · 2022Review
- The Impact of National Health Insurance Coverage on Compliance With Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea.Clinical and experimental otorhinolaryngology · 2022Article
- Cardiovascular Outcomes in Sleep-Disordered Breathing: Are We Under-estimating?Frontiers in neurology · 2022Review
- Continuous positive airway pressure reduces the incidence of atrial fibrillation in patients with obstructive sleep apnea: A Meta-Analysis and Systematic Review.Spartan medical research journal · 2022Article
- Prevalence and correlates of overweight and obesity among adolescents in northeastern China: a cross-sectional study.BMJ open · 2020Article
- Use of positive airway pressure in mild cognitive impairment to delay progression to dementia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Obstructive Lung Disease and Obstructive Sleep Apnea (OLDOSA) cohort study: 10-year assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: The association of positive airway pressure (PAP) with reduced mortality in patients with obstructive sleep apnea (OSA) remains uncertain. Objective: To investigate the association between PAP prescription and mortality. Design, Setting, and Participants: This multicenter, population-based cohort study evaluated data from the Sleep Heart Health Study (SHHS), a long-term observational cohort study that included participants between 1995 and 1998, with a mean follow-up of 11.1 years. Analyses were performed in September 2018. Within the SHHS, we compared patients with obesity and severe OSA with (n = 81) and without (n = 311) prescription of PAP therapy, after matching patients from each group by age, sex, and apnea-hypopnea index. Exposures: Self-reported use of PAP. Main Outcomes and Measures: All-cause mortality. Results: Of 392 study participants, 316 (80.6%) were men, and mean (SD) age was 63.1 (11.0) years. Ninety-six deaths occurred; 12 among the prescribed-PAP group and 84 among the nonprescribed-PAP group, yielding crude incidence rates of 12.8 vs 24.7 deaths per 1000 person-years. In Cox multivariate analysis, the hazard ratio (HR) of all-cause mortality for prescribed PAP therapy was 0.38 (95% CI, 0.18-0.81). After propensity matching, the HR of all-cause mortality for prescribed PAP therapy was 0.58 (95% CI, 0.35-0.96). According to survival curves, the difference in mortality appears 6 to 7 years after initiation of PAP therapy. Conclusions and Relevance: Positive airway pressure prescription is associated with reduced all-cause mortality, and this association appears several years after PAP initiation. If replicated, these findings may have strong clinical implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.