Evidence map›Paper›PMID 30973512›Full record

ArticleSpine2019

The Role of Type I Diabetes in Intervertebral Disc Degeneration.

Fabrizio Russo, Luca Ambrosio, Kevin Ngo, Gianluca Vadalà, Vincenzo Denaro, Yong Fan, Gwendolyn Sowa, James D Kang, Nam Vo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Spine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. COVID-19 Pandemic Increases the Impact of Low Back Pain: A Systematic Review and Metanalysis.International journal of environmental research and public health · 2022
    Pooled it
  2. Pooled it
  3. The Effects of Workplace Interventions on Low Back Pain in Workers: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
  4. Article
  5. Article
  6. Review
  7. Tissue engineering strategies for treating intervertebral disc degeneration.Frontiers in bioengineering and biotechnology · 2025
    Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Fabrizio RussoDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
Luca AmbrosioDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
Kevin NgoFerguson Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Gianluca VadalàDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
Vincenzo DenaroDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
Yong FanInstitute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA.
Gwendolyn SowaDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh Medical Cancer, University of Pittsburgh, Pittsburgh, PA.
James D KangDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Nam VoFerguson Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Università Campus Bio-Medico · ITUniversity of Pittsburgh Medical Center · USAllegheny Health Network · USBrigham and Women's Hospital · USUPMC Hillman Cancer Center · US

Funding

The role of cellular senescence in intervertebral disc agingR01AG044376 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VO, NAM V · 2013 to 2017
$1.5M
NIA NIH HHS R01 AG044376
6 · The paper itself

Abstract

STUDY

designAn experimental laboratory study.

objectiveTo investigate the pathogenesis of intervertebral disc degeneration (IDD) in a murine model of type 1 diabetes mellitus (DM), namely nonobese diabetic (NOD) mouse. SUMMARY OF BACKGROUND DATA: IDD is a leading contributor of low back pain, which represents one of the most disabling symptoms within the adult population. DM is a chronic metabolic disease currently affecting one in 10 adults in the United States. It is associated with an increased risk of developing IDD, but the underlying process remains poorly understood.

methodsTotal disc glycosaminoglycan content, proteoglycan synthesis, aggrecan fragmentation, glucose transporter gene expression, and apoptosis were assessed in NOD mice and wild-type euglycemic control mice. Spinal structural and molecular changes were analyzed by micro-computed tomography, histological staining (Safranin-O and fast green), and quantitative immunofluorescence (anti-ADAMTS-4 and -5 antibodies).

resultsCompared with euglycemic controls, NOD mice showed increased disc apoptosis and matrix aggrecan fragmentation. Disc glycosaminoglycan content and histological features of NOD mice did not significantly differ from those of euglycemic littermates.

conclusionThese data demonstrate that DM may contribute to IDD by increasing aggrecan degradation and promoting cell apoptosis, which may represent early indicators of the involvement of DM in the pathogenesis of IDD. LEVEL OF EVIDENCE: N/A.

Indexed as

Intervertebral Disc DegenerationAnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Mice

Identifiers

PMID30973512
PMCPMC6697217
OpenAlexW2938173180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.