ArticleeLife2019
Dual separable feedback systems govern firing rate homeostasis.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Persistent adaptation through dual-timescale regulation of ion channel properties.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Homeostatic preservation of action potential waveform by Notch and Nerfin-1.Current biology : CB · 2026Article
- Persistent Adaptation through Dual-Timescale Regulation of Ion Channel Properties.bioRxiv : the preprint server for biology · 2025Article
- Regulation of presynaptic homeostatic plasticity by glial signalling in Alzheimer's disease.The Journal of physiology · 2025Review
- Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells.The Journal of physiology · 2025Article
- Deficiency in transmitter release triggers homeostatic transcriptional changes that increase presynaptic excitability.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Behavioral resilience via dynamic circuit firing homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Restoration of Shal/KCellular and molecular life sciences : CMLS · 2025Article
- Motor neurons within a network use cell-type specific feedback mechanisms to constrain relationships among ion channel mRNAs.Journal of neurophysiology · 2023Article
- Neuronal morphology enhances robustness to perturbations of channel densities.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity.bioRxiv : the preprint server for biology · 2023Article
- Neuron populations use variable combinations of short-term feedback mechanisms to stabilize firing rate.PLoS biology · 2023Article
- Article
- Towards the Neuroevolution of Low-level artificial general intelligence.Frontiers in robotics and AI · 2022Article
- Distinct molecular pathways govern presynaptic homeostatic plasticity.Cell reports · 2021Article
- Age-related changes in Kv4/Shal and Kv1/Shaker expression in Drosophila and a role for reactive oxygen species.PloS one · 2021Article
- Activity-dependent compensation of cell size is vulnerable to targeted deletion of ion channels.Scientific reports · 2020Article
- Article
- Firing Rate Homeostasis Can Occur in the Absence of Neuronal Activity-Regulated Transcription.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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Authors and funding
5 authors.
Funding
Abstract
Firing rate homeostasis (FRH) stabilizes neural activity. A pervasive and intuitive theory argues that a single variable, calcium, is detected and stabilized through regulatory feedback. A prediction is that ion channel gene mutations with equivalent effects on neuronal excitability should invoke the same homeostatic response. In agreement, we demonstrate robust FRH following either elimination of Kv4/Shal protein or elimination of the Kv4/Shal conductance. However, the underlying homeostatic signaling mechanisms are distinct. Eliminating Shal protein invokes
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